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. 2019 Jan 16;6:87–94. doi: 10.1016/j.ibror.2019.01.006

Fig. 4.

Fig. 4

The effects of a high dose IV ketamine (40 mg/kg/2 h) on pERK protein levels in the mPFC, amygdala, and hippocampus of rats. A: IV ketamine increased pERK levels in the mPFC. B: IV ketamine had no effect on pERK levels in the amygdala, C: IV ketamine increased pERK levels in dorsal hippocampus. NF/SAL: No fear conditioning & IV saline infusion, NF/KET: No fear conditioning & IV ketamine infusion, F/SAL: Fear conditioning & IV saline infusion, F/KET: Fear conditioning & IV ketamine infusion. Data shown as mean ± SEM. A two-way ANOVA main effect of ketamine (#p < 0.05).