Table 1.
Transcripts with altered gene expression in the ME/CFS group compared to healthy controls (P < 0.01).
| Gene symbol | Gene name | P-value | Fold change |
|---|---|---|---|
| IL8 | Interleukin-8 | 2.5 × 10−6 | 5.6 |
| NFKBIA | NF-κB inhibitor alpha | 2.0 × 10−5 | 2.4 |
| TNFAIP3 | Tumour necrosis factor alpha-induced protein 3 | 1.3 × 10–4 | 3.6 |
| JUN | Jun proto-oncogene | 3.8 × 10−4 | 2.5 |
| PER1 | Period circadian protein homolog 1 | 8.8 × 10−4 | 2.3 |
| UBE2D3 | Ubiquitin conjugating enzyme E2 D3 | 2.2 × 10−3 | 2.0 |
| RBBP6 | E3 Ubiquitin-protein ligase RBBP6 | 2.3 × 10−3 | 2.1 |
| NAMPT | Nicotinamide phosphoribosyltransferase | 2.3 × 10−3 | 1.9 |
| IER3 | Immediate early response 3 | 2.7 × 10−3 | 2.0 |
| ZC3H12A | Zinc finger CCCH-type containing 12A | 2.8 × 10−3 | 1.8 |
| CREM | CAMP responsive element modulator | 2.8 × 10−3 | 1.9 |
| RIPK2 | Receptor interacting serine/threonine kinase 2 | 3.3 × 10−3 | 1.6 |
| PMAIP1 | Phorbol-12-myristate-13-acetate-inducing protein 1/immediate-early-response protein APR | 3.3 × 10−3 | 2.3 |
| PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | 3.6 × 10−3 | 1.7 |
| ENC1 | Ectodermal-neural cortex 1 | 4.3 × 10−3 | 2.2 |
| PMPCB | Peptidase, mitochondrial processing beta subunit | 4.3 × 10−3 | 1.9 |
| G3BP2 | G3BP stress granule assembly factor 2 | 4.5 × 10−3 | 2.0 |
| PIGA | Phosphatidylinositol glycan anchor biosynthesis class A | 4.9 × 10−3 | 1.8 |
| CCNL1 | Cyclin L1 | 5.3 × 10−3 | 1.6 |
| SOCS3 | Suppressor of cytokine signalling 3 | 5.3 × 10−3 | 1.8 |
| CSRNP1 | Cysteine and serine rich nuclear protein 1 | 5.7 × 10−3 | 1.6 |
| ZNF274 | Zinc finger protein 247 | 6.1 × 10−3 | 1.6 |
| USP3 | Ubiquitin specific peptidase 3 | 6.2 × 10−3 | 1.7 |
| PILRB | Paired immunoglobin-like type 2 receptor beta | 7.3 × 10−3 | 1.5 |
| DDX3X | DEAD-box helicase 3, X-linked | 8.2 × 10−3 | 1.5 |
| KLHL15 | Kelch like family member 15 | 9.2 × 10−3 | 1.8 |
| ETF1 | Eukaryotic translation termination factor 1 | 1.0 × 10−2 | 1.8 |
| ANKRD46 | Ankyrin repeat domain-containing protein 46 | 2.4 × 10−3 | 0.25 |
| LPAR1 | Lysophosphatidic acid receptor 1 | 4.3 × 10−3 | 0.15 |
| PCDHGC3 | Protocadherin gamma-c3 | 5.8 × 10−3 | 0.15 |
| ZNF202 | Zinc finger protein 202 | 6.8 × 10−3 | 0.14 |
| HS3ST3B1 | Heparin sulphate glucosamine-3-o-sulfotransferase 3B1 | 8.0 × 10−3 | 0.26 |
| DCUN1D3 | DCN1-like protein 3 | 1.0 × 10−2 | 0.23 |
ME/CFS: myalgic encephalomyelitis/chronic fatigue syndrome.