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Qualitative MRI Comparison. Three T1 axial 1.5 T MRIs comparing HDL2, HD and a normal control case. Image 1: 35-year-old HD subject with abnormal HTT allele = 49 triplet repeats. Image 2: 32-year-old HDL2 subject with abnormal JPH3 = 53 triplet repeats. Image 3: 32-year-old normal control subject. The HDL2 and HD subjects show qualitatively similar grey and white matter atrophy with caudate nuclei and putaminal volume loss compared to the normal control.
