HD, HDL2 and control groups basal ganglia, thalamic and hippocampal volumes. The estimated least-squares (LS) means from the regression are depicted in the figure in a three-way comparison among HD, HDL2 and control groups. Statistical significance is denoted by a symbol. Error bars denote the 95% confidence interval for the mean. Significance was set at p < .008. Symbols: **: HD, HDL2 < Control, ^: HDL2 < HD < Control, ^^: HDL2 < Control, HD where significance was reached. LS = Least-squares means, Nucleus acc = Nucleus accumbens.