Fig. 4.

HD, HDL2 and control cerebrospinal fluid and total intracranial volumes. The estimated least-squares (LS) means from the regression are depicted in the graph in a three-way comparison among the HD, HDL2 and control groups showing cerebrospinal fluid volumes and total intracranial volumes. Note that total intracranial volume was divided by 20 to fit to the graph scale. Statistical significance is shown with a symbol. Error bars denote the 95% confidence interval for the mean and significance was set at p < .008. Symbols denote #: Control < HD < HDL2. ##: HD, HDL2 < Control where significance was reached. LS = least squares mean, CSF=Cerebrospinal fluid.