Table 1.
Table showing subject demographic data and MRI volumes. a. Subject ages, age of disease onset, duration of disease and triplet repeat length. b. Unadjusted volumetric analysis of selected subcortical structures, hippocampi and total intracranial volumes in cm3. HD = Huntington's Disease, HDL2 = Huntington's Disease like 2, n = number SD = Standard Deviation.
| 1a Demographics and Genetics | HDL2 | HD | Controls |
|---|---|---|---|
| Number of participants | 9 | 11 | 9 |
| Male: Female | 5:4 | 6:5 | 5:4 |
|
| |||
| Mean (SD) | Mean (SD) | Mean (SD) | |
| Age at MRI (years) | 47.6 (9.1) | 46.0 (12.4) | 42.6 (9.1) |
| Abnormal repeat length (n) | 47.0 (3.5) | 44.9 (3.2) | – |
| Duration of disease (years) | 5.6 (3.0) | 6.6 (4.8) | – |
| Age at onset(years) | 42.0 (10.2) | 39.4 (13.1) | – |
|
| |||
| 1b Region Volume (cm3) | Mean (SD) | Mean (SD) | Mean (SD) |
| Left thalamus | 5.156 (0.671) | 6.453 (0.868) | 6.628 (0.698) |
| Right thalamus | 4.885 (0.805) | 6.232 (0.745) | 6.269 (0.643) |
| Left putamen | 2.147 (0.452) | 2.615 (0.233) | 4.771 (0.637) |
| Right putamen | 2.249 (0.389) | 2.698 (0.263) | 4.714 (0.502) |
| Left caudate | 1.010 (0.455) | 1.528 (0.485) | 3.359 (0.548) |
| Right caudate | 1.080 (0.475) | 1.667 (0.488) | 3.392 (0.629) |
| Left globus pallidus | 0.812 (0.190) | 0.749 (0.103) | 1.297 (0.311) |
| Right globus pallidus | 0.772 (0.150) | 0.766 (0.101) | 1.371 (0.323) |
| Left amygdala | 0.747 (0.230) | 0.743 (0.143) | 0.841 (0.171) |
| Right amygdala | 0.665 (0.170) | 0.755 (0.141) | 0.834 (0.266) |
| Left nucleus accumbens | 0.159 (0.050) | 0.174 (0.043) | 0.266 (0.075) |
| Right nucleus accumbens | 0.179 (0.067) | 0.232 (0.068) | 0.289 (0.059) |
| Intracranial volume | 1437.9 (112.7) | 1424.1 (118.5) | 1424.6 (156.5) |