Table 2.
Table comparing the Huntington's Disease Like 2, Huntington's Disease and the Normal control groups basal ganglia mean volume significant differences across multiple covariates (controlling for age at MRI, controlling for duration of disease, controlling for abnormal repeat length and controlling for age at onset) Two-tailed significance: P < .008. G. pallidus = Globus Pallidus, HDL2 = Huntington's Disease Like 2, HD = Huntington's Disease, N. Accumbens = Nucleus accumbens.
| Region | Comparison between HDL2, HD and control groups controlling for age at MRI |
Comparison between HDL2 and HD groups controlling for duration of disease |
Comparison between HDL2 and HD groups controlling for abnormal repeat length |
Comparison between HDL2 and HD groups controlling for age at onset |
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|---|---|---|---|---|---|---|---|---|
| Significant differences | P value | Significant differences | P value | Significant differences | P value | Significant differences | P value | |
| Left Thalamus | HDL2 < HD, Control | 0,0007 | HDL2 < HD | 0,0015 | HDL2 < HD | 0,0049 | HDL2 < HD | 0,0012 |
| Right Thalamus | HDL2 < HD, Control | 0,0005 | HDL2 < HD | 0,0008 | HDL2 < HD | 0,0032 | HDL2 < HD | 0,0006 |
| Left Putamen | HDL2, HD < Control | <0.0001 | HDL2 < HD | 0,0083 | HDL2 < HD | 0,0063 | Not Significant | 0,011 |
| Right Putamen | HDL2 < HD < Control | <0.0001 | HDL2 < HD | 0,0064 | HDL2 < HD | 0,0014 | HDL2 < HD | 0,0081 |
| Left Caudate | HDL2, HD < Control | <0.0001 | Not Significant | 0,023 | Not Significant | 0,027 | Not Significant | 0,034 |
| Right Caudate | HDL2, HD < Control | <0.0001 | Not Significant | 0,010 | Not Significant | 0,018 | Not Significant | 0,019 |
| Left G. pallidus | HDL2, HD < Control | <0.0001 | Not Significant | 0,45 | Not Significant | 0,41 | Not Significant | 0,42 |
| Right G. Pallidus | HDL2, HD < Control | <0.0001 | Not Significant | 0,81 | Not Significant | 0,80 | Not Significant | 0,97 |
| Left Amygdala | Not Significant | 0,11 | Not Significant | 0,35 | Not Significant | 0,27 | Not Significant | 0,35 |
| Right Amygdala | Not Significant | 0,27 | Not Significant | 0,22 | Not Significant | 0,16 | Not Significant | 0,25 |
| Left N. Accumbens | HDL2, HD < Control | 0,0016 | Not Significant | 0,38 | Not Significant | 0,16 | Not Significant | 0,54 |
| Right N. Accumbens | Not Significant | 0,011 | Not Significant | 0,018 | Not Significant | 0,10 | Not Significant | 0,10 |