Table 2.

Percentage of male and female worm killing at different concentrations of test compounds.

	Serial No	PDE inhibitors	% Worm killing
			Male worms						Female worms
			100 μM	50 μM	25 μM	10 μM	5 μM	EC50 male (μM)	100 μM	50 μM	25 μM	10 μM	5 μM	EC50 female (μM)
Killing from 50% to 100% (Class I)	1	NPD-0274*	100	88	25	0	0	32	0	0	0	0	0	NE
	2	NPD-0029	91	33	0	0	0	59	0	0	0	0	0	NE
	3	NPD-0356	88	71	29	0	0	36	0	0	0	0	0	NE
	4	NPD-0048	100	50	33	0	0	41	14	0	0	0	0	>100
	5	NPD-1012	60	50	0	0	0	68	0	0	0	0	0	NE
	6	NPD-1246	100	50	0	0	0	50	100	57	0	0	0	50
	7	NPD-1253	100	66	0	0	0	49	0	0	0	0	0	NE
	8	NPD-2904	73	0	0	0	0	97	0	0	0	0	0	NE
	9	NPD-1014	100	67	0	0	0	49	0	0	0	0	0	NE
	10	NPD-1211	88	56	0	0	0	48	56	13	0	0	0	93
	11	NPD-1085	78	13	0	0	0	76	0	0	0	0	0	NE
	12	NPD-1013	70	0	0	0	0	98	0	0	0	0	0	NE
Egg insult (Class II)	13	NPD-0298*	33	0	0	0	0	>100	0	0	0	0	0	NE
	14	NPD-0264*	12	0	0	0	0	>100	0	0	0	0	0	NE

Controls: PZQ was 100% effective against both male and female worms at all concentrations tested (100, 50, 25, 10 and 5  μM), and DMSO (negative control, solvent; 0.125%–2%) had no effect on worm viability.

NE, no effect.