Table 1.
Baseline characteristics of the study subjects
| Characteristics | Healthy adults (N = 1200) |
Patients with underlying illnesses (N = 300) |
Patients with malignancy (N = 49) |
Patients with diabetes mellitus (N = 180) |
Patients with autoimmune diseases (N = 10) |
Patients with chronic renal diseases (N = 61) |
|
|---|---|---|---|---|---|---|---|
| Sex | Male | 607 (51%) | 188 (63%)* | 26 (53%) | 120 (67%)* | 2 (20%)** | 40 (66%)* |
| Age (y) | Mean ± SD | 62.0 ± 8.0 | 66.0 ± 8.0 | 71.0 ± 9.0* | 65.0 ± 8.0* | 61.0 ± 7.0 | 69.0 ± 8.0* |
| 50–59 | 530 (44%) | 63 (21%)* | 3 (6%)* | 46 (26%)* | 4 (40%) | 10 (16%)* | |
| 60–69 | 425 (35%) | 129 (43%) | 21 (43%) | 80 (44%) | 4 (40%) | 24 (39%) | |
| 70+ | 245 (20%) | 108 (36%) | 25 (51%) | 54 (30%) | 2 (20%) | 27 (44%) | |
| History of HZ | Present | 155 (13%) | 49 (16%) | 11 (22%)** | 28 (16%) | 1 (10%) | 9 (15%) |
| Previous vaccination | Present | 3 (0.3%) | 3 (1%)** | 2 (4%)* | 1 (1%) | 0 (0%) | 0 (0%) |
| White blood cells (/μL) | Mean ± SD | – | 6289 ± 1685 | 5386 ± 1223 | 6505 ± 1811 | 6100 ± 520 | 5980 ± 1430 |
| HbA1c (%) | Mean ± SD | – | – | – | 7.0 ± 1.0 | – | – |
| Duration of diabetes mellitus (y) | Mean ± SD | – | – | – | 8.0 ± 7.0 | – | – |
| Creatinine (mg/dL) | Mean ± SD | – | – | – | – | – | 0.99 ± 0.15 |
| eGFR (mL/min/1.73 m2) | Mean ± SD | – | – | – | – | – | 53 ± 4 |
| Dialysis | Present | – | – | – | – | – | 0 (0%) |
Data are expressed as n (%) unless otherwise indicated
HZ Herpes zoster, SD Standard deviation
*P < 0.05, **P < 0.1 (compared with the proportion of subjects among healthy adults)