Table 1.
We implemented RWBRMDA on esophageal cancer for potential disease-related miRNA prediction and conducted the first pattern of case study, in which the disease-miRNA associations recorded in HMDD v2.0 were used as training samples and miRNAs without known associations with currently considered diseases were regarded as test samples. According to the prediction results, among the top 10 and 50 potential esophageal cancer related miRNAs, 10 and 47 were confirmed by miR2Disease and dbDEMC databases
| miRNA | Evidence | miRNA | Evidence |
|---|---|---|---|
| hsa-mir-29b | dbDEMC | hsa-mir-18a | dbDEMC |
| hsa-mir-1 | dbDEMC | hsa-mir-221 | dbDEMC |
| hsa-mir-19b | dbDEMC | hsa-mir-7 | dbDEMC |
| hsa-mir-16 | dbDEMC | hsa-mir-15b | dbDEMC |
| hsa-let-7e | dbDEMC | hsa-mir-106a | dbDEMC |
| hsa-mir-29a | dbDEMC | hsa-mir-218 | unconfirmed |
| hsa-let-7d | dbDEMC | hsa-mir-10b | dbDEMC |
| hsa-mir-106b | dbDEMC | hsa-mir-132 | dbDEMC |
| hsa-mir-146b | dbDEMC | hsa-mir-30c | dbDEMC |
| hsa-mir-222 | dbDEMC | hsa-mir-429 | dbDEMC |
| hsa-mir-24 | dbDEMC | hsa-mir-93 | dbDEMC |
| hsa-mir-200b | dbDEMC | hsa-mir-199b | dbDEMC |
| hsa-mir-181b | dbDEMC | hsa-mir-124 | dbDEMC |
| hsa-let-7f | unconfirmed | hsa-mir-107 | dbDEMC, miR2Disease |
| hsa-mir-181a | dbDEMC | hsa-mir-133b | dbDEMC |
| hsa-let-7i | dbDEMC | hsa-mir-23b | dbDEMC |
| hsa-mir-9 | dbDEMC | hsa-mir-127 | dbDEMC |
| hsa-let-7 g | dbDEMC | hsa-mir-206 | dbDEMC |
| hsa-mir-125b | dbDEMC | hsa-mir-20b | dbDEMC |
| hsa-mir-17 | dbDEMC | hsa-mir-122 | unconfirmed |
| hsa-mir-195 | dbDEMC | hsa-mir-224 | dbDEMC |
| hsa-mir-142 | dbDEMC | hsa-mir-18b | dbDEMC |
| hsa-mir-182 | dbDEMC | hsa-mir-27b | dbDEMC |
| hsa-mir-30a | dbDEMC | hsa-mir-373 | dbDEMC, miR2Disease |
| hsa-mir-125a | dbDEMC | hsa-mir-302b | dbDEMC |