Table 3.
We conducted case study of breast cancer in the second way by RWBRMDA, in which we removed all the known breast cancer related miRNAs to simulate a new disease without any known associations. Then we verified the prediction results based on HMDD v2.0 database, miR2Disease and dbDEMC database. As a result, among the top 10 and 50 potential miRNAs, 10 and 49 were confirmed
| miRNA | Evidence | miRNA | Evidence |
|---|---|---|---|
| hsa-mir-146a | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-146b | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-21 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-221 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-1 | dbDEMC,HMDD v2.0 | hsa-mir-210 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-29b | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-24 | dbDEMC,HMDD v2.0 |
| hsa-let-7a | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-200b | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-155 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-106b | dbDEMC,HMDD v2.0 |
| hsa-mir-145 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-18a | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-223 | dbDEMC,HMDD v2.0 | hsa-mir-181a | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-126 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-34c | dbDEMC,HMDD v2.0 |
| hsa-mir-19b | dbDEMC,HMDD v2.0 | hsa-mir-19a | dbDEMC,HMDD v2.0 |
| hsa-let-7b | dbDEMC,HMDD v2.0 | hsa-mir-181b | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-29a | dbDEMC,HMDD v2.0 | hsa-mir-200c | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-16 | dbDEMC,HMDD v2.0 | hsa-let-7f | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-let-7c | dbDEMC,HMDD v2.0 | hsa-mir-133a | dbDEMC,HMDD v2.0 |
| hsa-mir-17 | miR2Disease,HMDD v2.0 | hsa-mir-196a | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-15a | dbDEMC,HMDD v2.0 | hsa-let-7i | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-29c | dbDEMC,miR2Disease,HMDD v2.0 | hsa-let-7 g | dbDEMC,HMDD v2.0 |
| hsa-mir-34a | dbDEMC,HMDD v2.0 | hsa-mir-203 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-143 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-142 | unconfirmed |
| hsa-let-7e | dbDEMC,HMDD v2.0 | hsa-mir-9 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-150 | dbDEMC | hsa-mir-195 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-199a | dbDEMC,HMDD v2.0 | hsa-mir-205 | dbDEMC,miR2Disease,HMDD v2.0 |
| hsa-mir-125b | miR2Disease,HMDD v2.0 | hsa-mir-92a | HMDD v2.0 |
| hsa-mir-222 | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-34b | dbDEMC,HMDD v2.0 |
| hsa-let-7d | dbDEMC,miR2Disease,HMDD v2.0 | hsa-mir-182 | dbDEMC,miR2Disease,HMDD v2.0 |