Table 4.
Lymphoma was conducted as a case study in the third way, in which we only used known disease-miRNA association based on HMDD v1.0 database as test samples to assess the robustness of the prediction model in the different datasets, and then we verified the prediction results according to HMDD v2.0 database, miR2Disease, and dbDEMC database. As a result, among the top 10 and 50 potential lymphoma related miRNAs, 10 and 44 were confirmed
| miRNA | Evidence | miRNA | Evidence |
|---|---|---|---|
| hsa-mir-223 | dbDEMC | hsa-mir-200b | dbDEMC,HMDD v2.0 |
| hsa-mir-15b | dbDEMC | hsa-mir-199a | dbDEMC |
| hsa-mir-29c | dbDEMC,HMDD v2.0 | hsa-mir-95 | dbDEMC |
| hsa-mir-106a | dbDEMC | hsa-mir-183 | dbDEMC |
| hsa-mir-146a | dbDEMC,HMDD v2.0 | hsa-let-7e | dbDEMC |
| hsa-mir-99b | dbDEMC | hsa-mir-141 | dbDEMC |
| hsa-mir-100 | dbDEMC | hsa-let-7c | dbDEMC |
| hsa-mir-145 | dbDEMC | hsa-let-7a | dbDEMC |
| hsa-mir-143 | dbDEMC | hsa-mir-128b | unconfirmed |
| hsa-mir-155 | dbDEMC,HMDD v2.0 | hsa-mir-21 | dbDEMC,HMDD v2.0 |
| hsa-mir-222 | dbDEMC | hsa-mir-29b | dbDEMC |
| hsa-let-7 g | dbDEMC | hsa-mir-34c | unconfirmed |
| hsa-mir-101 | dbDEMC,HMDD v2.0 | hsa-mir-214 | dbDEMC |
| hsa-mir-224 | dbDEMC | hsa-mir-127 | dbDEMC |
| hsa-mir-34a | dbDEMC | hsa-let-7b | dbDEMC |
| hsa-mir-146b | unconfirmed | hsa-mir-132 | dbDEMC |
| hsa-mir-221 | dbDEMC | hsa-mir-137 | dbDEMC |
| hsa-mir-125b | unconfirmed | hsa-mir-376c | unconfirmed |
| hsa-let-7i | dbDEMC | hsa-mir-181b | dbDEMC |
| hsa-mir-203 | dbDEMC,HMDD v2.0 | hsa-mir-139 | dbDEMC,HMDD v2.0 |
| hsa-mir-126 | dbDEMC,HMDD v2.0 | hsa-mir-122 | dbDEMC,HMDD v2.0 |
| hsa-mir-335 | dbDEMC | hsa-mir-31 | dbDEMC |
| hsa-mir-196b | unconfirmed | hsa-mir-9 | dbDEMC |
| hsa-mir-140 | dbDEMC | hsa-mir-181d | dbDEMC |
| hsa-mir-191 | dbDEMC | hsa-mir-206 | dbDEMC |