Table 1.
Patient characteristics at enrolment
| General characteristics | Responders (n = 16) | Non-responders (n = 24) | p value |
|---|---|---|---|
| Age (years) | 72 [70–77] | 64 [54–75] | 0.34 |
| Gender (male/female) | 14/2 | 14/10 | 0.07 |
| Body mass index (kg/m2) | 24 [21–27] | 24 [23–26] | 0.85 |
| SAPS II | 46 [44–49] | 45 [41–48] | 0.43 |
| Temperature (°C) | 37.2 [36.8–37.4] | 36.9 [36.1–37.3] | 0.45 |
| Ventilator settings (baseline) | |||
| PEEP (cmH2O) | 5.0 [5.0–7.0] | 5.0 [5.0–6.3] | 0.77 |
| Pressure support (cmH2O) | 10.0 [8.8–10.0] | 10.0 [10.0–10.0] | 0.82 |
| VT (mL/kg ideal body weight) | 6.8 [5.9–7.4] | 7.0 [6.6–7.9] | 0.34 |
| PaO2/FiO2 (ratio) | 310 [280–354] | 302 [274–330] | 0.65 |
| RR (breaths/min) | 15 [13–18] | 13 [10–15] | 0.02 |
| HR/RR ratio | 6.2 [5.0–6.5] | 5.9 [5.0–6.4] | 0.71 |
| Vasoactive agents, n; (μg kg− 1 min− 1) | |||
| Norepinephrine | 6; (0.2 [0.2–0.3]) | 7; (0.2 [0.1–0.2]) | 0.85 |
| Dopamine | 2; (5.6 [4.8–5.9]) | 0 | 0.89 |
| Acute circulatory failure origin, n; (%) | |||
| Sepsis/septic shock | 6 (37.5) | 10 (41.7) | 0.99 |
| Hypovolemia | 7 (43.8) | 8 (33.3) | 0.53 |
| Trauma | 0 | 1 (4.1) | 0.99 |
| Intracranial diseases | 3 (18.7) | 5 (20.9) | 0.99 |
Data presented as median (25th–75th IQR) unless otherwise specified
IQR interquartile, SAPS simplified acute physiology score, PEEP positive end-expiratory pressure, VT tidal volume, PaO2/FiO2 arterial partial pressure of oxygen/fraction of inspired oxygen, RR respiratory rate, HR heart rate