Table 3.
Variations in SAP, PP and SVI and slope following sigh application in responders and non-responders
| Hemodynamic variables | Responders | Non-responders | p value | AUC (CI95) | ROC-curve sensitivity (%) | ROC-curve specificity (%) | ROC-curve best cutoff |
|---|---|---|---|---|---|---|---|
| Sigh15 | |||||||
| Nadir of SAP (%) | −5.8 (− 12.3/−3.2) | −4.8 (−6.5/−2.5) | 0.19 | NA | NA | NA | NA |
| Nadir of PP (%) | −10.7 (− 18.6/−6.0) | −6.3 (− 14.3/−4.1) | 0.10 | NA | NA | NA | NA |
| Nadir of SVI (%) | −1.7 (−2.6/−0.9) | − 1.9 (−2.5/−1.0) | 0.91 | NA | NA | NA | NA |
| Sigh25 | |||||||
| Nadir of SAP (%) | − 18.0 (−8.6/− 21.8) | −13.8 (−7.3/−18.3) | 0.004 | 0.77 (0.61–0.93) | 50.0 (29.1–70.8) | 87.5 (61.5–98.4) | −17% |
| Nadir of PP (%) | −23.8 (−15.3/−38.6) | −23.4 (− 12.3/−26.3) | 0.002 | 0.78 (0.63–0.93) | 70.8 (48.9–87.0) | 75.0 (47.6–92.0) | − 17% |
| Nadir of SVI (%) | −1.0 (−9.8/8.2) | −8.7 (−3.2/−15.8) | 0.38 | 0.58 (0.40–0.77) | NA | NA | NA |
| Sigh35 | |||||||
| Nadir of SAP (%) | − 24.9 (−19.3/−31.0) | −13.8 (− 7.3/−18.3) | 0.0003 | 0.83 (0.70–0.95) | 62.5 (35.4–84.0) | 91.6 (73.0–98.0) | − 14% |
| Nadir of PP (%) | −38.9 (− 35.1/−53.5) | −23.4 (− 12.3 / -26.3) | < 0.0001 | 0.91 (0.82–0.99) | 75 (47.6–92.7) | 91.6 (73.0–98.9) | −35% |
| Nadir of SVI (%) | −22.8 (− 13.7/−27.5) | −8.7 (− 3.2/−15.8) | 0.0002 | 0.83 (0.71–0.95) | 68.7 (41.3–88.9) | 87.5 (67.4–97.0) | −21% |
| Slope | |||||||
| Slope of SAP | −10.4° (− 11.9/−8.6) | −1.5° (− 3.0/−0.20) | < 0.0001 | 0.99 (0.99–1.01) | 100.0 (79.4–100.0) | 95.8 (78.8–99.9) | −4.4° |
| Slope of PP | − 7.6° (− 9.3/−6.4) | −3.7° (− 5.1/−2.1) | < 0.0001 | 0.91 (0.77–0.97) | 68.7 (41.3–88.9) | 95.8 (78.8–99.9) | −7.0° |
| Slope of SVI | −3.3° (− 3.8/−2.2) | −1.5° (− 2.5/−0.9) | < 0.0001 | 0.83 (0.68–0.93) | 56.2 (29.8–80.2) | 91.6 (73.0–98.9) | −3.2° |
Data presented as median (25th–75th IQR) and as percentage of variation with respect to baseline (nadir, see text for further explanations). SAP systolic arterial pressure, PP pulse pressure, SVI stroke volume index, AUC area under the curve, CI confidence interval, ROC receiver operating characteristic, NA not applicable