Table 2.

Preclinical Mouse Models for RA and IBD

Model	Features	Type	References
Collagen type II-induced arthritis (CIA)	Induced by collagen type II emulsified in complete Freund's adjuvant. Incidence and chronicity depend on susceptibility of mouse strain and collagen being used.	Induced	Luross and Williams (2001); Labelle and Hynes (2012)
KBxN arthritis (KBN)	Mice display T and B cell responses to glucose-6-phosphate isomerase on cartilage surface.	Spontaneous	Kyburz and Corr (2003)
SKG arthritis (SKG)	Inflammatory arthritis associated with a point mutation in ZAP-70. Microbiota can affect disease presentation.	Spontaneous	Sakaguchi and others (2003)
IL-1 receptor antagonist−/− arthritis (IL-1ra−/−)	Lack of IL-1 receptor antagonist results in spontaneous destructive arthritis. IL-17 dependent.	Spontaneous	Horai and others (2000)
AOM/DSS (IBD)	Chemical induction of DNA damage by AOM combined with repeated epithelial damage by DSS mimic key features of CA-CRC.	Induced	Parang and others (2016)

AOM, azoxymethane; CA-CRC, colitis-associated colorectal cancer; DSS, dextran sodium sulfate; IBD, inflammatory bowel disease; IL, interleukin.