Fig. 4.

Parameter optimization of the disease progression model. Upon applying dynamical simulations using the NKI data set, this figure assesses which seed region is most likely to reproduce the differences in node strength measured between ADNI control and ADNI patients. For each region, we explored the parameter space given by $\alpha$ and ${\beta }^{AD}$ to find the minimum cost function (see subsection 2.3.3). The hippocampus (HIPP) turned out to be the very first region affected by Alzheimer's disease. Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; NKI, Nathan Kline Institute-Rockland Sample. Expansions for the seed region abbreviations are given in Supplementary Table 1.