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. 2019 Jan 22;10:4. doi: 10.3389/fgene.2019.00004

Table 2.

Top 30 proteins obtained by the different methods in the telomere-length maintenance case study.

Propagation EC DADA RSS RSS_SD RDPN
1 VPS2015 LIP2 VPS2015 TFG2 SAE28,13 VPS241,10
2 SSB1 RNH203 SRN21,10 SCW10 GBP27,14 SDS35
3 SSA1 RPI1 SSA1 RPB3 TEX16 SRN21,10
4 RPN11 RNH202 SSB1 SUB2 HRB14 MGM1
5 HHT1 PMT5 RNH203 DOA412 THO26 THO26
6 SRN21,10 SRN21,10 RPN11 CPR7 VPS2015 RSC816
7 CRM1 RFU1 RNH202 RPO21 CPR7 VPS2115
8 HHT2 FLO11 HHT1 GBP27,14 PAF1 VPS2015
9 HHF1 SPL2 CRM1 RSC816 SUB2 GAL1112
10 HSP82 MVB12 MGM1 DLT1 RAP13 RPO21
11 CDC28 VPS2015 HHT2 UBP16 SRN21,10 VPS411,10
12 RNH203 MGM1 HHF1 SUP35 BUD17 MED22
13 RSP5 FMS1 HSP82 VPS241,10 OLA1 GBP27,14
14 RNH202 NTG2 RSP5 RAP13 RIM8 VPS331,10
15 SSB2 SAY1 VPS241,10 HRB14 MTG2 SRB62
16 RPO21 SCW10 RPO21 TEX16 RSC816 MED72
17 HHF2 YKR051W PEP5 HTB1 RPI1 PEP5
18 DSN1 BSC1 VPS161,10 GAL1112 SUP35 VPS81,10
19 MGM1 YBR063C CDC28 HTA2 RSC3 RXT25
20 CMR1 VPS241,10 SSB2 SCP160 VPS81,10 RNH203
21 VPS241,10 PUT3 THO26 YPK9 DOA412 MED82
22 RVB1 MLH3 HHF2 HHT2 MVB12 VPS41,10
23 RVB2 IBA57 DSN1 NTG2 PEP5 RGR116
24 TOM1 CIA2 VPS331,10 STH1 ALG3 VPS161,10
25 RPC82 MHF1 VPS411,10 HHF1 REB1 DOA412
26 SSC1 ERD2 CMR1 MRX1 SIR29,11 RNH202
27 PEP5 BUD17 SRB42 RGR116 RSC9 CTI65
28 SRB42 CTF812 GAL1112 YPR202W TFG2 HRB14
29 HTA2 RIM8 RGR116 SIR412 YJL070C RAP13
30 MMS22 VPS381,10 MED82 SRB4 SCW10 TEX16

Proteins in green are related to the TLM mechanism by the following explanations or references: 1TLM, belongs to the VPS pathway; 2part of the mediator complex (with SRB2, SRB3, SRB8, SSN2, SSN3, SSN8, GAL11, MED1, NUT1, PGD1, RGR1, and all TLMs); 3this is the main telomere-length determining protein; 4paralog of GBP2, the telomere-binding protein; 5part of RPD3 complex, as DEP1, SAP30, and SIN3 (TLMs); 6part of the THO/TREX complex (with THP2, HPR1, MFT1 and SOH1, and all TLMs); 7telomere binding protein; 8regulator of the MRX complex that processes telomeres; 9affects telomere chromatin, although not telomere length; 10Dieckmann et al. (2016); 11Ellahi et al. (2015); 12Gatbonton et al. (2006); 13Hardy et al. (2014); 14Konkel et al. (1995); 15Shachar et al. (2008); 16Ungar et al. (2009).