Table 1.

Results of three recent European multicentre trials evaluating CT colonography screening

Study acronym (first author and year)	Number of invitees	Population age range (years)	Participation  rate (%)		Diagnostic yield; advanced neoplasms per 100 participants		Diagnostic yield; advanced neoplasms per 100 invitees
			CTC	Comparator(s)	CTC	Comparator	CTC	Comparator
COCOS (Stoop et al 2012)46 (Tutein et al 2015)51	8,844 82b	Never screened 50–75	34	OC - 22	6.1a 8.6b	OC - 8.7	2.1 2.9b	OC - 1.9
SAVE (Sali et al 2016)45	16,087	Never screened 54–65	28c 25d	FIT - 50d OC - 15	5.5c 4.9d	FIT - 1.7e OC - 7.2	1.5c 1.2d	FIT - 0.9e OC - 1.1
PROTEUS1 & 2 (Regge et al 2017)44	42,929	Never screened 58–60	30f	FS - 27f	5.1a	FS - 4.7a	–	–

CTC, computed tomographic colonography; OC, optical colonoscopy.

^aUsing a threshold of 10 mm or greater to precipitate referral for colonoscopy. Patients with 6–9 mm polyps were initially enrolled in CTC follow-up.

^bAfter inclusion of the follow-up cohort of patients with 6–9 mm polyps detected at initial CTC.

^cReduced preparation CTC group.

^dFull-preparation CTC group.

^eData from PROTEUS1.