Table 2.
Association Studies of GRK4 Variants in Hypertensive or Normotensive Subjects
| GRK4 Variants |
Hypertensive Subjects | Normotensive Subjects | ||||
|---|---|---|---|---|---|---|
| Ethnic Group (Year) |
Single or Multi-locus Analyses | Hypertension Phenotype | Ethnic Group (Year) |
Single or Multi-locus Analyses |
Blood Pressure or Sodium Excretion | |
| R65L (rs2960306) |
Ghanaian (2004) | R65L and ACE | not classified60 | Euro- and African-American (2006) | Single-locus | Increased SBP64 |
| European ancestry (2012) | Single-locus | Salt sensitivity62 | ||||
| Euro- and African-American (2006) | Single-locus | Stress-induced UNaV reduction63 | ||||
| A142V (rs1024323) |
Japanese (2006) | Single-locus | low-renin hypertension59 | Japanese (2006) | R65L, A142V, and A486V | Impaired natriuretic response to dopaminergic stimulation59 |
| Japanese (2006) | A142V and CYP11B2 | low-renin hypertension59 | ||||
| Japanese (2006) | R65L, A142V, and A486V | salt-sensitive hypertension59 | ||||
| A486V (rs1801058) |
Italian (2002) | Single-locus | Mild salt-sesitive hypertension52 |
|||
| Euro- Australian (2004) | Single-locus | not classified53 | ||||
| Chinese (2006) | Single-locus | not classified54 | ||||
| Chinese (2006) | Single-locus | not classified55 | ||||
| African- American (2010) | Single-locus | negative association58 | ||||
| African-derived Brazilian (2012) | A486V and NOS3 | not classified66 | ||||
Abbreviations: SBP, systolic blood pressure; UNaV, Urinary sodium excretion.