. 2018 Dec 2;2018:7301530. doi: 10.1155/2018/7301530

Table 2.

COT effects on neuropsychological tests.

Study	Design	Intervention conditions	Sample	Cognitive measures	Cognitive task results after training
Rosen et al. [14]	RCT double-blind	Auditory processing training Computer-based activities	COT MCI CCI MCI	RBANS scores	NS
Rosen et al. [14]	RCT double-blind	Auditory processing training Computer-based activities	COT MCI CCI MCI	RBANS immediate memory COT MCI > CCI MCI	p = 0.027; Cohen's d = 1.38

Belleville et al. [17]	CGT single–blind	Mnemonic strategy training	COT HC COT MCI	Word list recall MCI = HC	p < 0.05, η² = 0.21
				MCI < HC	p < 0.05, η² = 0.16
				Word list Immediate recall MCI = HC	p < 0.001; η² = 0.73
				Performance on FMRI scan MCI = HC	p < 0.01, η² = 0.23

Hampstead et al. [18]	Case control	Face name Association strategy	COT MCI TS US	Post fMRI scan recognition task TS = US	p = 0.001
				TS > US	p = 0.002
				Reaction time TS	p = 0.04

Hampstead et al. [20]	RCT single blind	Object location Association training Stimuli Exposition	COT HC COT MCI CCI HC CCI MCI	Object location Recognition task TS-COT group > CCI group	p = 0.026, pη² = 0.155
				TS-HC > MCI	p < 0.001, pη² = 0.343
				US-HC > MCI	p < 0.001, pη² = 0.314

Balardin et al. [21]	CGT single blind	Semantic encoding strategy training	COT HC CCI MCI	Word list free Recall HC > MCI	p = 0.001
				MCI = HC	p < 0.001
				SR > UR	p < 0.001
				Semantic cluster HC = MCI	p = 0.272
				Semantic cluster HC = MCI	p < 0.001
				Mean number of clusters MCI < HC	p = 0.047

Lin et al. [15]	RCT single blind	Visual speed of processing and attention training Computer-based activities	COT MCI CCI MCI	UFV-reaction time COT MCI > CCI MCI	p = 0.02, η² = 0.26
				Working memory COT MCI > CCI MCI	p = 0.01, η² = 0.28
				Cognitive control COT MCI > CCI MCI	p = 0.03, η² = 0.21
				Verbal fluency	NS
				IADL completion time	NS

De Marco et al. [16]	RCT single blind	Cognitive training Social engagement	COT MCI CCI MCI	CCRI	NS

RCT: randomized controlled trial; CGT: controlled group trial; COT: cognitive oriented treatment; CCI: control condition intervention; MCI: mild cognitive impairment; HC: healthy controls; TS: trained stimulus; US: untrained stimulus; SR: semantic related; UR: unrelated; UVF: used field of view; IADLs: instrumental activities of daily living; CCRI: cognitive change ratio index; p: p values; η²: eta-squared; η²: partial eta-squared; NS: not significant results.