Table 1.
Patient laboratory value after initiation of immunotherapy with nivolumab.
| Parameter | Nivolumab therapy | Nivolumab withdrawal | ||||||
|---|---|---|---|---|---|---|---|---|
| Day 0 | Day 105 | Day 130 | Admission | Discharge | Month 1 | Month 2 | Month 6 | |
| Serum creatinine (μmol/L) | 79.56 | 176.8 | 362.4 | 433.1 | 433.2 | 274.1 | 194.5 | 159.1 |
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| eGFR∗ (ml/min/1.73m2) | 92.5 | 35,2 | 14,8 | 11.9 | 14.8 | 20.7 | 31.4 | 40 |
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| Serum sodium (mmol/L) | - | 145 | - | 138 | 143 | 137 | 140 | 143 |
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| Serum potassium (mmol/L) | - | 5.3 | - | 5.8 | 4.3 | 5.4 | 4.5 | 4.7 |
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| Serum calcium (mmol/L) | - | 2.45 | - | 2.2 | 2.2 | 2.4 | 2.2 | 2.25 |
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| Serum phosphate (mmol/L) | - | - | - | 1.35 | 1.32 | 1.42 | 0.97 | 1.23 |
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| Eosinophil count (cells/μL, %) | - | - | 320 (6.9%) | 260 (4.0%) | 230 (3.7%) | 80 (0.9%) | 50, (0.5%) | |
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| CRP (nmol/L) | - | - | - | 780.0 | 207.6 | 138.1 | 85.7 | 57.1 |
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| UPE (mg/day) | - | - | - | 180 | - | 190 | 201 | 266 |
CRP= C-reactive protein; eGFR= estimated glomerular filtration rate; UPE= urine protein excretion.
∗CKD-EPI equation was used to estimate eGFR