Table 2.

Summary of APT treatment protocol.

No.	Author  (year)	Time of pressing	Frequency of pressing	Duration of pressing	Acupressure technique	Main acupoints
1	Huang et al. (2015)	1-2 min each time	3-5 times a day	27 days	Seeds were pressed to produce sourness, distention, numbness, pain and hot sensation that was tolerable to patients	Shenmen
2	Huo et al. (2014)	1-2 min each time	4-5 times a day	Eight weeks	Seeds were pressed to produce mild hot and pain sensation that was tolerable to patients	Shenmen, Occiput, Neurasthenia Area, Neurasthenia Point, Subcortex, Heart, and Deep Sleep Point
3	Li et al. (2016)	NR	3-5 times a day	21 days	Seeds were pressed to produce redness, distention and hot sensation that was tolerable to patients	Shenmen, Occiput, Subcortex, Brain, and Endocrine
4	Lin et al. (2018)	NR	3-5 times a day	6 days	Seeds were pressed to produce sourness, distention, and hot sensation that was tolerable to patients	Shenmen
5	Qian et al. (2016)	At least 2 min each time	3-5 times a day	Two weeks	Seeds were pressed to produce mild distention and pain sensation that was tolerable to patients	Shenmen, Heart, Subcortex, Sympathetic, and Endocrine
6	Su et al. (2017)	NR	3-5 times a day	10 days	Seeds were pressed to produce sourness, pain and hot sensation that was tolerable to patients	Shenmen, Subcortex, Sympathetic, Heart, and Kidney
7	Wan et al. (2017)	1-2 min each time	3-5 times a day	1 month	Seeds were pressed to produce distention, numbness, pain and hot sensation that was tolerable to patients	Shenmen, Endocrine, Heart, and Sympathetic
8	Wang et al. (2018)	3-5 min each time	NR	NR	NR	Shenmen, Sympathetic, Subcortex, and Heart
9	Wu et al. (2012)	3 min each time	3-5 times a day	Four weeks	Seeds were pressed to produce redness, distention and hot sensation that was tolerable to patients	Shenmen, Subcortex, Brain, and Endocrine
10	Xing et al. (2014)	1-3 min each time	3-5 times a day	14 days	NR	Shenmen, Subcortex, Endocrine, and Sympathetic
11	You et al. (2015)	2 min each time	3 times a day	NR	Seeds were pressed to produce sourness, distention, numbness that was tolerable to patients	Heart, Lung, Kidney, Liver, Spleen, and Shenmen
12	Zhang et al. (2016)	0.5-1 min each time	3 times a day	Four weeks	Seeds were pressed to produce hot sensation that was tolerable to patients	Shenmen, Sympathetic, Brain, Heart, Liver, and Kidney
13	Zhang et al. (2017)	3-5 min each time	NR	NR	NR	Shenmen, Sympathetic, Subcortex, and Heart
14	Zhou et al. (2013)	1-2 min each time	4-5 times a day	1 month	Seeds were pressed to produce sourness, distention, numbness and hot sensation that was tolerable to patients	Shenmen, Heart, Sympathetic, and Subcortex