Table 3.
Univariate analysis of clinicopathological factors predictive of central/lateral lymph node metastasis (CLNM/LLNM).
| Parameters | Total | CLNM (-) | CLNM (+) | P | LLNM (-) | LLNM (+) | P |
|---|---|---|---|---|---|---|---|
| Gender | |||||||
| Male | 189 | 111 (58.7%) | 78 (41.3%) | <0.001 | 180 (95.2%) | 9 (4.8%) | 0.372 |
| Female | 596 | 445 (74.7%) | 151 (25.3%) | 576 (96.6%) | 20 (3.4%) | ||
| Age | |||||||
| <55 | 653 | 450 (68.9%) | 203 (31.1%) | 0.009 | 626 (95.9%) | 27 (4.1%) | 0.205 |
| ≥55 | 132 | 106 (80.3%) | 26 (19.7%) | 130 (98.5%) | 2 (1.5%) | ||
| Tumor size | |||||||
| ≤5 mm | 417 | 338 (81.1%) | 79 (18.9%) | <0.001 | 413 (99.0%) | 4 (1.0%) | <0.001 |
| >5 mm | 368 | 218 (59.2%) | 150 (40.8%) | 343 (93.2%) | 25 (6.8%) | ||
| Extrathyroidal extension | |||||||
| No | 736 | 534 (72.6%) | 202 (27.4%) | <0.001 | 714 (97.0%) | 22 (3.0%) | <0.001 |
| Yes | 49 | 22 (44.9%) | 27 (55.1%) | 42 (85.7%) | 7 (14.3%) | ||
| Multifocality | |||||||
| Unifocal | 559 | 409 (73.2%) | 150 (26.8%) | 0.023 | 546 (97.7%) | 13 (2.3%) | 0.001 |
| Multifocal | 226 | 147 (65.0%) | 79 (35.0%) | 210 (92.9%) | 16 (7.1%) | ||
| Bilaterality | |||||||
| Unilateral | 645 | 468 (72.6%) | 177 (27.4%) | 0.022 | 627 (97.2%) | 18 (2.8%) | 0.004 |
| Bilateral | 140 | 88 (62.9%) | 52 (37.1%) | 129 (92.1%) | 11 (7.9%) | ||
| Complicated with lymphocytic thyroiditis | |||||||
| No | 664 | 469 (70.6%) | 195 (29.4%) | 0.778 | 636 (95.8%) | 28 (4.2%) | 0.070 |
| Yes | 121 | 87 (71.9%) | 34 (28.1%) | 120 (99.2%) | 1 (0.8%) |
CLNM: central lymph node metastasis; LLNM: lateral lymph node metastasis.