Table 4.
Registered clinical trials of MSCs in renal fibrosis and CKD (ClinicalTrial.gov, updated September 2018).
| Registered no. | Status | Title | Population (age: year-old) | Phase | Source of MSCs | Location | Start date |
|---|---|---|---|---|---|---|---|
| NCT00659620 | Unknown | Mesenchymal stem cell transplantation in the treatment of chronic allograft nephropathy | 20 (18-60) | 1 and 2 | Bone marrow | Fuzhou, China | May 2008 |
| NCT00733876 | Completed | Allogeneic multipotent stromal cell treatment for acute kidney injury following cardiac surgery | 15 (>18) | 1 | Bone marrow | Murray, Salt lake city, United States | August 2008 |
| NCT00734396 | Completed | Mesenchymal stem cells and subclinical rejection | 15 (18-65) | 1 and 2 | Bone marrow | Leiden, Netherlands | February 2009 |
| NCT01840540 | Completed | MSC for occlusive disease of the kidney | 6 (40-80) | 1 | Adipose | Rochester, United States | April 2013 |
| NCT01967186 | Unknown | Intraportal or intramuscular site for islets in simultaneous islet and kidney transplantation | 36 (18-65) | Not applicable | Bone marrow | The Nordic network for clinical islet transplantation | April 2007 |
| NCT02057965 | Recruiting | Mesenchymal stromal cell therapy in renal recipients | 70 (18-75) | 2 | Bone marrow | Leiden, Netherlands | March 2014 |
| NCT02166489 | Completed | Mesenchymal stem cell transplantation in patients with chronic renal failure due to polycystic kidney disease | 6 (18-60) | 1 | Bone marrow | Tehran, Iran | March 2014 |
| NCT02195323 | Completed | Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) in patients with chronic kidney disease (CKD) | 7 (25-60) | 1 | Bone marrow | Tehran, Iran | April 2014 |
| NCT02266394 | Recruiting | Hypoxia and inflammatory injury in human renovascular hypertension | 42 (40-80) | 1 | Adipose | Birmingham, Rochester, Jackson, United States | October 2014 |
| NCT02387151 | Active, not recruiting | Allogeneic mesenchymal stromal cell therapy in renal transplant recipients | 10 (18-75) | 1 | Bone marrow | Leiden, Netherlands | March 2015 |
| NCT02565459 | Recruiting | MSC and kidney transplant tolerance (phase A) | 22 (18-75) | 1 | Bone marrow | Bergamo, Italy | September 2015 |
| NCT02966717 | Active, not recruiting | Rituximab combined with MSCs in the treatment of PNS (3-4 stages of CKD) | 116 (18-65) | 2 | Not mentioned | Guangzhou, China | August 2016 |
| NCT03321942 | Recruiting | Treatment of chronic renal failure with adipose tissue-derived mesenchymal stem cells | 100 (18-75) | Not applicable | Adipose | Xuzhou, China | January 2017 |