Table 1.

Demographic and clinical characteristics of patients according to novel autoantibody status.

	Novel antibody positive (n = 56)	Novel antibody negative (n = 80)	p value
Demographics
Age, years, mean (SD)	59.0 (10.5)	60.4 (12.4)	0.50
Female, n (%)	49 (87%)	66 (82%)	0.48
Dry eye-related symptoms, n (%)
Light sensitivity	22 (39%)	33 (41%)	0.86
Foreign body sensation/grittiness	39 (70%)	52 (65%)	0.58
Burning/tearing	27 (48%)	43 (54%)	0.60
Eye pain	18 (32%)	25 (31%)	0.99
Blurred vision	22 (39%)	30 (37%)	0.86
Dry eye measures, mean (SD)
Tear osmolarity (mOsm/L)	309 (22.6)	307 (14.6)	0.61
Schirmer test (mm)	6.6 (5.7)	8.5 (7.8)	0.27
Schirmer test ≤ 5 mm, n (%)	19 (63%)	20 (43%)	0.07
Total OSS (0-12)	6.4 (3.3)	6.0 (3.5)	0.56
Corneal staining (0-6)	2.7 (1.8)	2.5 (1.9)	0.57
Conjunctival staining (0-6)	3.7 (2.0)	3.6 (2.3)	0.74
OSS ≥ 5, n (%)	35 (66%)	48 (67%)	0.94
Schirmer ≤ 5 mm or OSS ≥ 5, n (%)	42 (78%)	58 (76%)	0.84
SS-Related Symptoms, n (%)
Dry mouth	18 (32%)	24 (30%)	0.85
Joint/muscle pain	12 (21%)	12 (15%)	0.37
Fatigue	6 (11%)	10 (12%)	0.79
Autoimmune Diseases
Sjögren's syndrome	9 (16%)	9 (11%)	0.41
Primary	8 (14%)	3 (4%)	0.051
Secondary	1 (2%)	6 (7%)	0.24
Other autoimmune diseases	10 (18%)	11 (14%)	0.57
SS diagnostic parameters
Anti-SSA	6 (11%)	7 (9%)	0.68
Anti-SSB	2 (4%)	3 (4%)	>0.99
RF	7 (13%)	7 (9%)	0.46
ANA ≥ 1 : 320	7 (13%)	7 (9%)	0.46
Positive biopsy	1/6 (17%)	1/7 (14%)	>0.99

Results are represented as mean (standard deviation) for continuous variables and number (percentage) for binary variables. The t-test was used for comparison of continuous variables and chi-squared testing for categorical variables between groups. SD: standard deviation; OSS: ocular staining score; SSA: Sjögren's syndrome-related antigen A; SSB: Sjögren's syndrome-related antigen B; RF: rheumatoid factor; ANA: antinuclear antibody.