Table 3.
Antileishmanial activity against Leishmania amazonensis and cytotoxicity against BALB/c peritoneal macrophages of Cinnamomum zeylanicum, Curcuma longa, and Origanum vulgare essential oils.
| Essential oils/ compounds | L. amazonensis IC50 | Cytotoxicity CC50 | SI | |
| Promastigote (µg/mL) | Intracellular amastigote (µg/mL) | Peritoneal macrophage (µg/mL) | ||
|
| ||||
| Cinnamomum zeylanicum | >500 a,b,c | n.d. | >1000 | n.d. |
| Curcuma longa | 308.4 ± 1.402 a,d,e | 63.3 ± 1.369 a | >1000 | >15.79 |
| Origanum vulgare | 405.5 ± 1.119 b,d,f | n.d. | >1000 | n.d. |
| Amphotericin B | 0.764 ± 0.139 c,e,f | 1.045 ± 0.145 a | 37.22 ± 1.834 | 35.6 |
Data represents mean ± standard deviation of at least two experiments realized in triplicate. CC50: cytotoxic concentration for 50% of cells; IC50: inhibitory concentration for 50% of parasites; SI: selectivity index; n.d.: not determined. Equal letters in the same column mean statistical difference between IC50 (p<0.0001) by one-way ANOVA and Tukey's multiple comparisons test.