Table 1.
Baseline characteristics of 28 patients with NK/T-cell LAHS
| Characteristics | No. of patients | % |
|---|---|---|
| Gender | ||
| Male | 18 | 64.3 |
| Female | 10 | 35.7 |
| Age at diagnosis (years) | ||
| >60 | 3 | 10.7 |
| ≤60 | 25 | 89.3 |
| ECOG | ||
| 0–1 | 13 | 46.4 |
| 2–3 | 15 | 53.6 |
| Ann Arbor stage | ||
| I + II | 19 | 67.9 |
| III + IV | 9 | 32.1 |
| Bone marrow involvement (n=13) | ||
| Yes | 3 | 23.1 |
| No | 10 | 76.9 |
| LDH level before HLH (n=22) | ||
| Normal | 13 | 59.1 |
| Elevated | 9 | 40.9 |
| Subtypes | ||
| UNKTL | 16 | 57.1 |
| EUNKTL | 12 | 42.9 |
| EBER positive (n=16) | ||
| Yes | 15 | 93.8 |
| No | 1 | 6.2 |
| Cutaneous involvement | ||
| Yes | 10 | 35.7 |
| No | 18 | 64.3 |
| NKPI | ||
| 0–1 | 18 | 64.3 |
| ≥2 | 10 | 35.7 |
| Neutropenia | ||
| I/II | 8 | 28.6 |
| III/IV | 9 | 32.1 |
| No | 11 | 39.3 |
| Anemia | ||
| I/II | 15 | 53.6 |
| III/IV | 13 | 46.4 |
| Fever | ||
| Yes | 27 | 96.4 |
| No | 1 | 3.6 |
| Splenomegaly (n=27) | ||
| Yes | 22 | 81.5 |
| No | 5 | 18.5 |
| Ferritin (ng/mL) (n=12) | ||
| ≥500 | 11 | 91.7 |
| <500 | 1 | 8.3 |
| Fibrinogen (g/L) (n=20) | ||
| ≤1 | 9 | 45 |
| >1 | 11 | 55 |
| Triglycerides (mmol/L) (n=25) | ||
| ≥3.0 | 12 | 48 |
| <3.0 | 13 | 52 |
| Thrombocytopenia | ||
| I/II | 10 | 35.7 |
| III/IV | 18 | 64.3 |
| LDH at HLH (U/L) (n=27) | ||
| >1,000 | 11 | 40.7 |
| ≤1,000 | 16 | 59.3 |
Abbreviations: EBER, EBV-encoded RNA; ECOG, Eastern Cooperative Oncology Group; EUNKTL, extra-upper aerodigestive tract NK/T-cell lymphoma; HLH, hemophagocytic lymphohistiocytosis; LDH, lactic dehydrogenase; NK, natural killer; NKPI, NK/T-cell lymphoma prognostic index; UNKTL, upper aerodigestive tract NK/T-cell lymphoma.