Table 2.
Characteristics of patients with NK/T LAHS between longer survival group and shorter survival group
| Characteristics | Shorter group | Longer group | P-value |
|---|---|---|---|
| Gender | |||
| Male | 8 | 4 | 0.829 |
| Female | 5 | 2 | |
| Age at diagnosis | |||
| Mean ± SD | 41.42±14.34 | 39.29±3.63 | 0.876 |
| Age at HLH | |||
| Mean ± SD | 42.37±13.82 | 41.82±5.08 | 0.876 |
| ECOG | |||
| 0–1 | 5 | 4 | 0.252 |
| 2–3 | 8 | 2 | |
| Ann Arbor stage | |||
| I + II | 10 | 4 | 0.637 |
| III + IV | 3 | 2 | |
| LDH level before HLH | |||
| Normal | 6 | 3 | 1 |
| Elevated | 4 | 2 | |
| Subtypes | |||
| UNKTL | 7 | 4 | 0.599 |
| EUNKTL | 6 | 2 | |
| EBER positive | |||
| Yes | 6 | 4 | 0.428 |
| No | 1 | 0 | |
| Cutaneous involvement | |||
| Yes | 6 | 3 | 0.876 |
| No | 7 | 3 | |
| Anemia | |||
| I/II | 7 | 4 | 0.599 |
| III/IV | 6 | 2 | |
| Splenomegaly | |||
| Yes | 12 | 1 | <0.001 |
| No | 0 | 5 | |
| Ferritin (ng/mL) | |||
| ≥500 | 1 | 4 | 0.121 |
| <500 | 1 | 0 | |
| Fibrinogen (g/L) | |||
| ≤1 | 6 | 0 | 0.026 |
| >1 | 3 | 4 | |
| Triglycerides (mmol/L) | |||
| ≥3.0 | 6 | 1 | 0.091 |
| <3.0 | 4 | 5 | |
| Thrombocytopenia | |||
| I/II | 4 | 3 | 0.419 |
| III/IV | 9 | 3 | |
| LDH at HLH (U/L) | |||
| >1,000 | 8 | 0 | 0.007 |
| ≤1,000 | 4 | 6 | |
Abbreviations: EBER, EBV-encoded RNA; ECOG, Eastern Cooperative Oncology Group; EUNKTL, extra-upper aerodigestive tract NK/T-cell lymphoma; HLH, hemophagocytic lymphohistiocytosis; LDH, lactic dehydrogenase; NK, natural killer; NKPI, NK/T-cell lymphoma prognostic index; UNKTL, upper aerodigestive tract NK/T-cell lymphoma.