Table 4.
Genotypic distributions and allelic associations of the studied SNPs with asthma control
| Gene | SNP_ID | Genotype distribution and analysis | Allelic distribution and analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Genotype | Controlled asthma, n (%) | Uncontrolled asthma, n (%) | P-value | Allele | Controlled asthma, n (%) | Uncontrolled asthma, n (%) | P-value | Adjusted P-value | ||
|
| ||||||||||
| ADRB2 | rs1042713 | AA | 6 (8.1) | 20 (12) | 0.107 | A | 40 (27) | 121 (36.2) | 0.048 | NS |
| AG | 28 (37.8) | 81 (48.5) | G | 108 (73) | 213 (63.8) | |||||
| GG | 40 (54.1) | 66 (39.5) | ||||||||
| rs1042714 | GG | 11 (15.3) | 10 (6) | 0.041 | G | 51 (35.4) | 82 (24.7) | 0.017 | NS | |
| GC | 29 (40.3) | 62 (37.4) | C | 93 (64.6) | 250 (75.3) | |||||
| CC | 32 (44.4) | 94 (56.6) | ||||||||
| ADH5 | rs1154400 | CC | 6 (8.3) | 16 (9.7) | 0.725 | C | 47 (32.6) | 103 (31.2) | 0.759 | NS |
| CT | 35 (48.6) | 71 (43) | T | 97 (67.4) | 227 (68.8) | |||||
| TT | 31 (43.1) | 78 (47.3) | ||||||||
| ARG1 | rs2781659 | GG | 12 (16.4) | 22 (13.6) | 0.847 | G | 62 (42.5) | 131 (40.4) | 0.678 | NS |
| GA | 38 (52.1) | 87 (53.7) | A | 84 (57.5) | 193 (59.6) | |||||
| AA | 23 (31.5) | 53 (32.7) | ||||||||
| CRHR1 | rs1876828 | AA | 5 (6.8) | 6 (3.6) | 0.361 | A | 31 (21.2) | 71 (21.3) | 0.995 | NS |
| AG | 21 (28.8) | 59 (35.3) | G | 115 (78.8) | 263 (78.7) | |||||
| GG | 47 (64.4) | 102 (61.1) | ||||||||
| rs242939 | GG | 1 (1.4) | 6 (3.5) | 0.833 | G | 16 (11) | 46 (13.4) | 0.449 | NS | |
| GA | 14 (19.2) | 34 (19.9) | A | 130 (89) | 296 (86.6) | |||||
| AA | 58 (79.4) | 131 (76.6) | ||||||||
| rs242941 | TT | 8 (11) | 25 (14.9) | 0.493 | T | 52 (35.6) | 120 (35.7) | 0.983 | NS | |
| TG | 36 (49.3) | 70 (41.7) | G | 94 (64.4) | 216 (64.3) | |||||
| GG | 29 (39.7) | 73 (43.4) | ||||||||
Abbreviations: SNP, single-nucleotide polymorphism; NS, not significant.