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. 2018 Dec 24;8(3):1550341. doi: 10.1080/2162402X.2018.1550341

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Overall change in hydrophobicity in human tumors positive for APOBEC-related mutagenesis.

Panel A. Correlation between the overall neo-peptide hydrophobicity change and the total number of APOBEC-related mutations in highly-mutated human tumors positive for APOBEC-related mutagenesis.Panels B-E. Comparison of neo-peptide hydrophobicity change in highly mutated tumors with or without APOBEC-related mutagenesis, in different subgroups of tumors (non-melanoma (B, D) and melanoma tumors (C, E)), considering the hydrophobicity scores before (B, C) or after (D, E) weighting by the mRNA-expression levels. Mean and 95% confidence intervals are represented in bold bars.