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. 2018 Dec 25;8(3):1557030. doi: 10.1080/2162402X.2018.1557030

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Detection of PD-1 mRNA isoforms and protein in IL-2 activated NK cells and in NK cells isolated from malignant PE. (a) Percentages of PD-1 surface expression in in vitro-activated NK cells isolated from HDs. (b) Analysis of PD-1 mRNA isoforms on NK cells. One representative HD, out of three analyzed, has been reported. (c) Total protein extracts isolated from in vitro-activated NK cells were analyzed for PD-1 expression. (d) Analysis of PD-1 splicing variants in NK from PE. (e) PD-1 protein profile of PE infiltrating NK cells. (f) sPD-1 has been studied in PE or supernatants (SN) of both resting and IL-2-activated NK cells isolated from HDs. Data for PE and HDs are relative to four and three different samples, respectively. sPD-1 concentration (pg/ml) has been calculated by use of a four-point-fit calibration curve of the standard dilutions.