Figure 2.
Concordance with previously described subclasses. Concordance between our subclasses and those described by TCGA Network and Tirosh et al. was determined by performing GSEA using the representative set of genes for each of the previously described subclasses.5,6 Concordance with the subclasses defined by Jönsson et al. was assessed by matching the gene expression-based centroid for each subclass with the Z-transformed p-values resulting from the pairwise class comparisons.4 Subsequently, Spearman’s rank correlations were calculated between the centroids and the ranked lists with the Z-transformed two-sided p-values. The thickness of the lines between subclasses indicates the significance level of concordance.