Table 4. Evaluation of 6TP, excretion metabolites, and synthesized 8-substituted analogs towards inhibition of UDPGDH and UGT-1A and cytotoxicity towards REH (acute lymphocytic leukemia) cancerous cell lines. All experiments were carried out in triplicate and standard error is reported.
| Compound | IC50 (μM) REH |
| 6TP | 2.94 (±0.48) |
| 6TU | >10 |
| 6TX | >10 |
| 8-OH-6TP | 9.91 (±2.36) |
| 18a (Br) | 9.54 (±0.97) |
| 18b (Cl) | 3.95 (±1.94) |
| 18c (F) | 4.71 (±1.40) |
| Doxorubicin | 0.285 (±0.08) |