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. Author manuscript; available in PMC: 2019 Jan 29.
Published in final edited form as: Lancet. 2012 Dec 15;380(9859):2163–2196. doi: 10.1016/S0140-6736(12)61729-2

Table 2:

Global years lived with disability (YLDs) for a comprehensive set of 289 causes and select sequelae in 1990 and 2010, for all ages, both sexes combined, and per 100 000

All ages YLDs (thousands)
YLDs (per 100 000)
1990 2010 1990 2010

All causes 583 393 (484 649-694 406) 777 401 (648 158-921 711) 333% 11 004 (9142-13 098) 11 283 (9407-13 378) 2.5%
Communicable, maternal, neonatal, and nutritional disorders 113 925 (85 875-148 463) 119 164 (91 399-152 096) 46% 2149 (1620-2800) 1730 (1327-2207) −19.5%
HIV/AIDS and tuberculosis 7681 (5222-10 722) 11 117 (7718-15 187) 44.7% 145 (99-202) 161 (112-220) 11.4%
Tuberculosis 6085 (4020-8737) 6774 (4500-9756) 11.3% 115 (76-165) 98 (65-142) −14.3%
HIV/AIDS 1596 (1132-2125) 4342 (3142-5629) 172.2% 30 (21-40) 63(46-82) 109.4%
HIV disease resulting in mycobacterial infection 220 (143-314) 1224 (793-1746) 456.8% 4(3-6) 18 (12-25) 328.4%
HIV disease resulting in other specified or unspecified diseases 1376 (967-1857) 3119 (2241-4107) 126.7% 26 (18-35) 45 (33-60) 74.4%
HIV pre-AIDS asymptomatic 376 (227-569) 889 (546-1338) 136.8% 7 (4-11) 13(8-19) 82.2%
HIV pre-AIDS symptomatic 289 (193-411) 531 (350-756) 83.6% 5 (4-8) 8 (5-11) 41.3%
AIDS with antiretroviral treatment 0 (0-0) 389 (251-578) .. 0 (0-0) 6 (4-8) ..
AIDS without antiretroviral treatment 711 (483-958) 1309 (913-1758) 84.2% 13 (9-18) 19 (13-26) 41.7%
Diarrhoea, lower respiratory infections, meningitis, and other common infectious diseases 18 579 (13 419-25 301) 19 921 (14 241-27 439) 7.2% 350 (253-477) 289 (207-398) −17.5%
Diarrhoeal diseases 7654 (5135-10 855) 8045 (5371-11 366) 5.1% 144 (97-205) 117 (78-165) −19.1%
Cholera 115 (59-188) 80 (42-134) −30.1% 2 (1-4) 1 (1-2) −46.2%
Other salmonella infections 263 (150-410) 341 (202-523) 29.8% 5(3-8) 5(3-8) −0.1%
Shigellosis 703 (391-1111) 744 (440-1147) 5.8% 13 (7-21) 11 (6-17) −18.6%
Enteropathogenic E coli infection 972 (438-1652) 845 (387-1416) −13.0% 18 (8-31) 12 (6-21) −33.1%
Enterotoxigenic E coli infection 889 (520-1409) 1065 (649-1643) 19.8% 17 (10-27) 15 (9-24) −7.8%
Campylobacter enteritis 753 (407-1211) 746 (416-1180) −1.0% 14 (8-23) 11 (6-17) −23.8%
Campylobacter enteritis 753 (406-1211) 746 (415-1181) −0.9% 14 (8-23) 11 (6-17) −23.8%
Guillain-Barre syndrome due to C enteritis 1 (0-1) 1 (1-2) 35.7% <0.5 (0-0.5) <0.5 (0-0.5) 4.4%
Amoebiasis 142 (84-217) 205 (126-314) 44.1% 3 (2-4) 3(2-5) 10.9%
Cryptosporidiosis 651 (312-1101) 661 (316-1096) 1.6% 12 (6-21) 10 (5-16) −21.8%
Rotaviral enteritis 1159 (624-1885) 1269 (701-2006) 9.5% 22 (12-36) 18 (10-29) −15.8%
Other diarrhoeal diseases 2007 (1027-3412) 2089 (1054-3521) 4.1% 38 (19-64) 30 (15-51) −19.9%
Typhoid and paratyphoid fevers 134 (25-348) 172 (33-435) 27.8% 3 (0-7) 2(0-6) −1.7%
Typhoid and paratyphoid fevers 124 (16-337) 159 (20-423) 27.8% 2(0-6) 2(0-6) −1.6%
Liver abscess and cysts due to typhoid and paratyphoid fevers 10 (7-15) 13 (8-20) 27.4% <0.5 (0-0.5) <0.5 (0-0.5) −1.9%
Lower respiratory infections 2113 (1444-2941) 2331 (1592-3240) 10.3% 40 (27-55) 34 (23-47) −15.1%
Influenza 510 (344-714) 583 (393-815) 14.2% 10 (6-13) 8(6-12) −12.1%
Influenza 510 (343-713) 582 (392-814) 14.2% 10 (6-13) 8(6-12) −12.1%
Guillain-Barre syndrome due to influenza 1 (1-2) 2(1-3) 34.3% <0.5 (0-0.5) <0.5 (0-0.5) 3.3%
Pneumococcal pneumonia 298 (203-414) 367 (248-509) 23.2% 6 (4-8) 5 (4-7) −5.2%
H influenzae type B pneumonia 216 (145-306) 201 (134-286) −6.6% 4(3-6) 3 (2-4) −28.2%
Respiratory syncytial virus pneumonia 52 (31-82) 36 (21-55) −31.3% 1 (1-2) 1 (0-1) −47.2%
Other lower respiratory infections 1037 (702-1459) 1144 (779-1589) 10.2% 20 (13-28) 17 (11-23) −15.2%
Upper respiratory infections 1438 (755-2542) 1728 (911-3050) 20.2% 27 (14-48) 25 (13-44) −7.5%
Upper respiratory infections 1437 (753-2541) 1727 (910-3048) 20.2% 27 (14-48) 25 (13-44) −7.5%
Guillain-Barre syndrome due to upper respiratory infections 1 (1-2) 2(1-3) 33.8% <0.5 (0-0.5) <0.5 (0-0.5) 3.0%
Otitis media 3794 (2456-5829) 4436 (2887-6668) 16.9% 72 (46-110) 64 (42-97) −10.0%
Otitis media 1359 (819-2150) 1613 (979-2594) 18.7% 26 (15-41) 23 (14-38) −8.7%
Hearing loss due to otitis media 2435 (1423-3929) 2824 (1669-4533) 16.0% 46 (27-74) 41 (24-66) −10.8%
Meningitis 2757 (1973-3732) 2628 (1857-3643) −4.7% 52 (37-70) 38 (27-53) −26.7%
Pneumococcal meningitis 920 (624-1298) 886 (595-1254) −3.7% 17 (12-24) 13(9-18) −25.9%
Spneumoniae meningitis 9 (5-14) 11 (6-17) 19.6% <0.5 (0-0.5) <0.5 (0-0.5) −8.0%
Long term sequelae due to S pneumoniae meningitis 571 (324-899) 488 (261-806) −14.5% 11 (6-17) 7 (4-12) −34.2%
Seizures due to S pneumoniae meningitis 80 (52-118) 79 (55-113) −0.4% 2(1-2) 1 (1-2) −23.4%
Hearing loss due to Spneumoniae meningitis 261 (154-420) 308 (185-500) 18.2% 5 (3-8) 4 (3-7) −9.0%
H influenzae type B meningitis 646 (429-933) 371 (247-524) −42.6% 12 (8-18) 5 (4-8) −55.8%
H influenzae type B meningitis 10 (6-17) 7 (4-12) −32.0% <0.5 (0-0.5) <0.5 (0-0.5) −47.7%
Long term sequelae due to H influenzae type B meningitis 448 (253-715) 233 (124-368) −48.4% 8(5-13) 3(2-5) −60.0%
Seizures due to H influenzae type B meningitis 65 (38-110) 31 (18-51) −52.2% 1(1-2) <0.5 (0-1) −63.3%
Hearing loss due to H influenzae type B meningitis 123 (74-198) 100 (60-160) −18.5% 2 (1-4) 1 (1-2) −37.3%
Meningococcal infection 424 (302-597) 403 (281-566) −4.8% 8 (6-11) 6 (4-8) −26.7%
Meningococcal infection 6 (4-10) 7 (4-12) 13.0% <0.5 (0-0.5) <0.5 (0-0.5) −13.0%
Long term sequelae due to meningococcal infection 195 (115-306) 165 (92-269) −15.2% 4(2-6) 2 (1-4) −34.8%
Seizures due to meningococcal infection 35 (23-52) 28 (18-40) −21.4% 1 (0-1) <0.5 (0-1) −39.5%
Hearing loss due to meningococcal infection 187 (110-297) 203 (119-325) 8.6% 4 (2-6) 3(2-5) −16.5%
Other meningitis 733 (509-1036) 930 (647-1361) 27.0% 14 (10-20) 14 (9-20) −2.3%
Other meningitis 37 (24-53) 49 (31-72) 34.4% 1 (0-1) 1 (0-1) 3.4%
Long term sequelae due to other bacterial meningitis infection 283 (157-446) 289 (149-476) 2.2% 5 (3-8) 4 (2-7) −21.4%
Seizures due to other bacterial meningitis infection 48 (32-71) 46 (31-66) −4.0% 1 (1-1) 1 (0-1) −26.1%
Hearing loss due to other bacterial meningitis infection 365 (221-572) 546 (322-883) 49.6% 7 (4-11) 8 (5-13) 15.1%
Encephalitis 183 (120-260) 205 (133-292) 12.6% 3 (2-5) 3 (2-4) −13.4%
Encephalitis 5 (3-9) 7 (4-12) 35.7% <0.5 (0-0.5) <0.5 (0-0.5) 4.4%
Motor cognitive impairments due to encephalitis 177 (117-253) 198 (128-283) 11.9% 3(2-5) 3 (2-4) −13.9%
Diphtheria <0'5 (0-2) <0.5 (0-1) −49.1% <0.5 (0-0.5) <0.5 (0-0.5) −60.9%
Whooping cough 181 (103-287) 122 (70-195) −32.5% 3(2-5) 2(1-3) −48.0%
Tetanus 78 (35-159) 21(9-43) −72.3% 1 (1-3) <0.5 (0-1) −78.7%
Tetanus 77 (35-158) 21(9-43) −72.3% 1 (1-3) <0.5 (0-1) −78.7%
Long-term sequelae from neonatal tetanus 1 (0-2) <0.5 (0-1) −73.2% <0.5 (0-0.5) <0.5 (0-0.5) −79.4%
Measles 106 (58-180) 31 (17-51) −70.8% 2(1-3) <0.5 (0-1) −77.5%
Varicella 142 (87-219) 202 (124-308) 42.0% 3 (2-4) 3 (2-4) 9.3%
Chickenpox 7 (2-16) 7 (2-16) −0.9% <0.5 (0-0.5) <0.5 (0-0.5) −23.8%
Herpes zoster 135 (84-209) 195 (120-295) 44.3% 3 (2-4) 3 (2-4) 11.0%
Neglected tropical diseases and malaria 23 491 (15 715-36 639) 22 219 (15 693-31 544) −5.4% 443 (296-691) 322 (228-458) −27.2%
Malaria 2662 (1257-4481) 4070 (1853-6980) 52.9% 50 (24-85) 59 (27-101) 17.7%
Malaria 433 (194-854) 498 (218-933) 14.8% 8(4-16) 7 (3-14) −11.6%
Anaemia due to malaria 2127 (833-3972) 3367 (1312-6294) 58.3% 40 (16-75) 49 (19-91) 21.8%
Motor cognitive impairments due to malaria 104 (41-273) 211(81-556) 102.8% 2(1-5) 3 (1-8) 56.0%
Chagas disease 324 (108-594) 303(106-573) −6.4% 6(2-11) 4(2-8) −28.0%
Acute Chagas disease 31 (7-62) 28 (7-59) −8.8% 1(0-1) <0.5 (0-1) −29.8%
Chronic heart disease due to Chagas disease 213 (38-429) 195 (36-411) −8.4% 4(1-8) 3 (1-6) −29.5%
Chronic digestive disease due to Chagas disease 73 (8-178) 67 (7-157) −8.5% 1(0-3) 1 (0-2) −29.6%
Heart failure due to Chagas disease 7 (4-10) 13 (8-19) 92.6% <0.5 (0-0.5) <0.5 (0-0.5) 48.2%
Leishmaniasis 113 (53-215) 124 (60-235) 10.2% 2 (1-4) 2(1-3) −15.2%
Visceral leishmaniasis 8 (2-16) 6(2-13) −17.2% <0.5 (0-0.5) <0.5 (0-0.5) −36.3%
Cutaneous leishmaniasis 105 (47-206) 118 (56-229) 12.2% 2 (1-4) 2(1-3) −13.7%
African trypanosomiasis 33 (12-86) 8(2-25) −75.2% 1(0-2) <0.5 (0-0.5) −80.9%
Schistosomiasis 1797 (923-3413) 2986 (1541-5666) 66.2% 34 (17-64) 43 (22-82) 27.9%
Schistosomiasis 696 (229-1579) 1148 (377-2607) 65.0% 13 (4-30) 17 (5-38) 27.0%
Mild diarrhoea due to schistosomiasis 1 (0-1) 1 (1-2) 77.2% <0.5 (0-0.5) <0.5 (0-0.5) 36.3%
Anaemia due to schistosomiasis 433 (219-766) 687 (344-1217) 58.8% 8 (4-14) 10 (5-18) 22.2%
Hepatomegaly due to schistosomiasis 104 (47-200) 185(84-355) 77.8% 2 (1-4) 3(1-5) 36.8%
Haematemesis due to schistosomiasis 39 (26-55) 69 (46-97) 76.6% 1(0-1) 1 (1-1) 35.9%
Ascites due to schistosomiasis 31 (21-44) 56 (38-77) 78.9% 1 (0-1) 1(1-1) 37.7%
Dysuria due to schistosomiasis 174 (80-334) 298 (135-572) 71.0% 3(2-6) 4(2-8) 31.5%
Bladder pathology due to schistosomiasis 159 (72-304) 268 (122-515) 68.9% 3 (1-6) 4 (2-7) 30.0%
Hydronephrosis due to schistosomiasis 162 (74-310) 277(126-533) 71.5% 3 (1-6) 4(2-8) 32.0%
Cysticercosis 484 (378-600) 457 (357-566) −5.5% 9(7-11) 7 (5-8) −27.3%
Echinococcosis 89 (44-187) 110 (55-228) 23.9% 2 (1-4) 2 (1-3) −4.7%
Chronic respiratory disease due to echinococcosis 2 (1-6) 3 (1-7) 22.8% <0.5 (0-0.5) <0.5 (0-0.5) −5.5%
Epilepsy due to echinococcosis 13 (6-28) 16 (8-32) 24.1% <0.5 (0-1) <0.5 (0-0.5) −4.5%
Abdominopelvic problems due to echinococcosis 73 (36-155) 91 (43-193) 23.9% 1 (1-3) 1 (1-3) −4.7%
Lymphatic filariasis 2368 (1551-3399) 2775 (1807-4000) 17.2% 45 (29-64) 40 (26-58) −9.9%
Lymphoedema 955 (585-1454) 1151 (698-1773) 20.5% 18 (11-27) 17 (10-26) −7.3%
Hydrocele due to lymphatic filariasis 1414 (842-2103) 1624 (981-2450) 14.9% 27 (16-40) 24 (14-36) −11.6%
Onchocerciasis 512 (361-687) 494 (360-656) −3.5% 10 (7-13) 7 (5-10) −25.7%
Skin disease due to onchocerciasis 407 (277-559) 352 (240-486) −13.3% 8(5-11) 5 (3-7) −33.3%
Vision loss due to onchocerciasis 105 (79-134) 142 (108-185) 34.5% 2(1-3) 2 (2-3) 3.5%
Trachoma 144 (104-189) 334 (243-438) 132.5% 3 (2-4) 5 (4-6) 78.9%
Dengue 6(2-13) 12 (6-23) 103.9% <0.5 (0-0.5) <0.5 (0-0.5) 56.9%
Dengue 5(2-11) 10 (5-20) 105.9% <0.5 (0-0.5) <0.5 (0-0.5) 58.5%
Post-dengue chronic fatigue syndrome 1 (0-2) 2 (0-4) 92.6% <0.5 (0-0.5) <0.5 (0-0.5) 48.2%
Yellow fever <0.5 (0-0.5) <0.5 (0-0.5) 15.1% <0.5 (0-0.5) <0.5 (0-0.5) −11-4%
Rabies <0.5 (0-1) <0.5 (0-1) −56.7% <0.5 (0-0.5) <0.5 (0-0.5) −66.7%
Intestinal nematode infections 8741 (4778-15 094) 4980 (2722-8442) −43-0% 165 (90-285) 72 (40-123) −56.2%
Ascariasis 3950(2080-6805) 1111 (618-1864) −71'9% 75 (39-128) 16 (9-27) −78.4%
Ascariasis infestation 1995 (1091-3254) 758 (419-1232) −62.0% 38 (21-61) 11 (6-18) −70.8%
Severe wasting due to ascariasis 49 (32-72) 43 (28-62) −12.8% 1 (1-1) 1(0-1) −32.9%
Mild abdominopelvic problems due to ascariasis 1906 (871-3673) 310 (139-598) −83.7% 36 (16-69) 4(2-9) −87.5%
Trichuriasis 857 (465-1420) 638 (349-1061) −25.5% 16 (9-27) 9 (5-15) −42.7%
Trichuriasis infestation 677 (367-1104) 504 (277-821) −25.6% 13 (7-21) 7 (4-12) −42.8%
Severe wasting due to trichuriasis 9(5-13) 9(5-13) −0.5% <0.5 (0-0.5) <0.5 (0-0.5) −23.4%
Mild abdominopelvic problems due to trichuriasis 171 (77-327) 126 (57-246) −26.3% 3 (1-6) 2 (1-4) −43.3%
Hookworm disease 3934(2056-6983) 3231(1695-5732) −17.9% 74 (39-132) 47 (25-83) −36.8%
Hookworm infestation 1315 (718-2150) 1011 (556-1655) −23.1% 25 (14-41) 15(8-24) −40.9%
Severe wasting due to hookworm disease 34 (21-49) 42 (27-61) 23.4% 1 (0-1) 1(0-1) −5.0%
Mild abdominopelvic problems due to hookworm disease 241(110-462) 217(98-422) −10.0% 5(2-9) 3(1-6) −30.8%
Anaemia due to hookworm disease 2344 (983-4348) 1962 (895-3672) −16.3% 44 (19-82) 28 (13-53) −35.6%
Food-borne trematodiases 2394 (635-8501) 1875 (708-4837) −21.7% 45 (12-160) 27 (10-70) −39.7%
Heavy clonorchiasis 367 (95-1145) 296 (100-822) −19.4% 7 (2-22) 4(1-12) −37.9%
Heavy fascioliasis 32 (18-53) 42 (26-65) 32.5% 1 (0-1) 1(0-1) 2.0%%
Heavy intestinal fluke infection 101 (58-179) 106 (64-170) 4.9% 2(1-3) 2(1-2) −19.3%
Heavy opisthorchiasis 48 (29-77) 60 (37-92) 27.0% 1 (1-1) 1(1-1) −2.3%
Cerebral paragonimiasis 57 (7-245) 43 (8-148) −25.2% 1 (0-5) 1 (0-2) −42.4%
Heavy paragonimiasis 1789 (233-7696) 1328 (280-4234) −25.8% 34 (4-145) 19 (4-61) −42.9%
Other neglected tropical diseases 3825 (2517-6057) 3690 (2556-5303) −3.5% 72 (47-114) 54 (37-77) −25.8%
Other neglected tropical disease 1007 (533-2568) 949 (657-1557) −5.8% 19 (10-48) 14 (10-23) −27.5%
Anaemia due to other neglected tropical diseases 2873 (1920-4163) 2800 (1857-4054) −2.5% 54 (36-79) 41 (27-59) −25.0%
Maternal disorders 1394 (935-2271) 1790 (1138-2936) 28.4% 26 (18-43) 26 (17-43) −1.2%
Maternal haemorrhage 143 (84-234) 98 (61-151) −31.7% 3 (2-4) 1 (1-2) −47.5%
Maternal haemorrhage 29 (18-46) 19 (12-29) −34.2% 1 (0-1) <0.5 (0-0.5) −49.4%
Anaemia due to maternal haemorrhage 114(65-193) 79 (47-124) −31.1% 2 (1-4) 1 (1-2) −47.0%
Maternal sepsis 80 (46-128) 42 (25-65) −48.4% 2(1-2) 1 (0-1) −60.3%
Hypertensive disorders of pregnancy 69 (41-111) 93 (53-151) 33.2% 1(1-2) 1 (1-2) 2.5%
Pre-eclampsia 60 (33-100) 83 (44-141) 38.9% 1(1-2) 1 (1-2) 6.9%
Eclampsia 4 (1-7) 3 (1-7) −14.6% <0.5 (0-0.5) <0.5 (0-0.5) −34.3%
Long-term sequelae for hypertensive disorders of pregnancy 6(1-15) 7 (2-15) 6.3% <0.5 (0-0.5) <0.5 (0-0.5) −18.2%
Obstructed labour 809 (458-1493) 1182 (641-2194) 46.0% 15(9-28) 17 (9-32) 12.4%
Obstructed labour 77 (40-140) 34 (19-57) −56.1% 1(1-3) <0.5 (0-1) −66.3%
Fistula 732 (390-1425) 1148 (601-2138) 56.8% 14 (7-27) 17 (9-31) 20.6%
Abortion 27 (15-52) 32 (19-59) 19.8% 1 (0-1) <0.5 (0-1) −7.8%
Other maternal disorders 264 (180-420) 343 (225-526) 30.1% 5(3-8) 5(3-8) 0.1%
Neonatal disorders 8422(6368-10706) 9464 (7167-11 937) 12.4% 159 (120-202) 137 (104-173) −13.5%
Preterm birth complications 2298 (1743-2895) 2982 (2236-3716) 29.7% 43 (33-55) 43 (32-54) −0.2%
Impairment due to preterm birth complications 2041 (1471-2613) 2636 (1882-3359) 29.1% 39 (28-49) 38 (27-49) −0.7%
Retinopathy of prematurity due to preterm birth complications 257 (154-376) 347 (212-508) 34.9% 5 (3-7) 5 (3-7) 3.8%
Neonatal encephalopathy (birth asphyxia/trauma) 5625 (4116-7298) 6132 (4471-8030) 9.0% 106 (78-138) 89 (65-117) −16.1%
Sepsis and other infectious disorders of the newborn baby 18 (9-32) 23 (12-40) 24.9% <0.5 (0-1) <0.5(0-1) −3.9%
Other neonatal disorders 481 (357-618) 328 (244-417) −31.8% 9(7-12) 5 (4-6) −47.5%
Nutritional deficiencies 49 887 (34 714-70 780) 49 942 (34 705-70 350) 0.1% 941(655-1335) 725 (504-1021) −23.0%
Protein-energy malnutrition 3200 (2071-4743) 2720(1766-3972) −15.0% 60 (39-89) 39 (26-58) −34.6%
Kwashiokor or marasmus due to protein-energy malnutrition 298 (155-520) 197 (103-339) −33.7% 6 (3-10) 3(1-5) −49.0%
Severe wasting due to protein-energy malnutrition 2906 (1803-4418) 2530 (1604-3772) −12.9% 55 (34-83) 37 (23-55) −33.0%
Iodine deficiency 3181 (2049-4912) 3889(2468-6136) 22.3% 60 (39-93) 56 (36-89) −5.9%
Goitre due to iodine deficiency 2902 (1823-4617) 3767 (2382-5990) 29.8% 55 (34-87) 55 (35-87) −0.1%
Idiopathic intellectual disability due to iodine deficiency 271 (181-386) 113 (73-167) −58.4% 5 (3-7) 2(1-2) −68.0%
Heart failure due to iodine deficiency 7(5-11) 10 (6-14) 33.3% <0.5 (0-0.5) <0.5 (0-0.5) 2.6%
Vitamin A deficiency 740 (565-941) 806 (612-1037) 9.0% 14 (11-18) 12 (9-15) −16.1%
Iron-deficiency anaemia 42 731 (28 506-61 896) 42 494 (28 170-61 626) −0.6% 806 (538-1167) 617 (409-894) −23.5%
Iron-deficiency anaemia 42 728 (28 497-61 897) 42 505 (28 166-61 656) −0.5% 806 (538-1168) 617(409-895) −23.5%
Heart failure due to iron-deficiency anaemia 17 (11-24) 24 (16-36) 46.7% <0.5 (0-0.5) <0.5(0-1) 12.9%
Other nutritional deficiencies 35 (31-44) 32 (24-36) −9.2% 1 (1-1) <0.5(0-1) −30.1%
Other communicable, maternal, neonatal, and nutritional disorders 4472 (3188-6195) 4711(3352-6562) 5.3% 84 (60-117) 68 (49-95) −18.9%
Sexually transmitted diseases excluding HIV 1111 (589-2072) 1298 (704-2439) 16.9% 21 (11-39) 19 (10-35) −10.0%
Syphilis 73 (3-156) 91 (4-200) 25.5% 1(0-3) 1 (0-3) −3.4%
Sexually transmitted chlamydial diseases 560 (268-1025) 669 (324-1233) 19.6% 11 (5-19) 10 (5-18) −8.0%
Sexually transmitted chlamydial diseases 507 (233-952) 609 (281-1143) 20.1% 10 (4-18) 9 (4-17) −7.6%
Salpingitis, inflammatory disease of cervix, and other female pelvic inflammatory diseases due to sexually transmitted chlamydial diseases 27 (16-43) 25 (15-40) −7.5% 1(0-1) <0.5(0-1) −28.8%
Infertility due to sexually transmitted chlamydial diseases 25 (9-53) 35 (14-72) 37.7% <0.5 (0-1) 1 (0-1) 6.0%
Gonococcal infection 184 (94-336) 249 (123-450) 35.1% 3(2-6) 4 (2-7) 4.0%
Gonococcal infection 147 (69-282) 207(96-390) 40.7% 3(1-5) 3 (1-6) 8.3%
Salpingitis, inflammatory disease of cervix, and other female pelvic inflammatory diseases due to gonococcal infection 20 (12-33) 19 (11-31) −7.7% <0.5 (0-1) <0.5 (0-0.5) −29.0%
Infertility due to gonococcal infection 17(7-35) 23 (9-47) 37.7% <0.5 (0-1) <0.5(0-1) 5.9%
Trichomoniasis 182 (0-549) 167 (0-493) −8.4% 3 (0-10) 2 (0-7) −29.5%
Other sexually transmitted diseases 112 (68-181) 122 (74-200) 9.3% 2 (1-3) 2 (1-3) −15.9%
Other sexually transmitted diseases 70 (42-111) 64 (39-105) −7.8% 1 (1-2) 1(1-2) −29.0%
Infertility due to other sexually transmitted diseases 42 (17-91) 58 (23-125) 37.7% 1 (0-2) 1 (0-2) 5.9%
Hepatitis 449 (230-810) 542 (280-981) 20.7% 8 (4-15) 8 (4-14) −7.1%
Acute hepatitis A 172 (85-294) 185 (95-311) 7.6% 3(2-6) 3(1-5) −17.2%
Acute hepatitis B 194 (24-456) 248 (28-585) 28.1% 4(0-9) 4(0-8) −1.4%
Acute hepatitis C 24 (4-50) 39 (7-79) 61.2% <0.5 (0-1) 1 (0-1) 24.1%
Acute hepatitis E 59 (20-121) 69 (24-142) 17.8% 1 (0-2) 1 (0-2) −9.3%
Leprosy 26 (12-48) 6 (3-11) −76.6% <0.5 (0-1) <0.5 (0-0.5) −82.0%
Other infectious diseases 2886 (1920-4175) 2864 (1902-4141) −0.8% 54 (36-79) 42 (28-60) −23.6%
Other infectious diseases 922 (615-1330) 957 (635-1386) 3.8% 17 (12-25) 14 (9-20) −20.2%
Anaemia due to other infectious diseases 2000 (1329-2897) 1947 (1292-2812) −2.7% 38 (25-55) 28 (19-41) −25.1%
Guillain-Barré syndrome due to other infectious diseases 1 (0-1) 1 (0-1) 35.8% <0.5 (0-0.5) <0.5 (0-0.5) 4.5%
Non-communicable diseases 435 400 (365 526-515 063) 611 076 (512 645-721 956) 40.3% 8213(6895-9715) 8869 (7440-10 478) 8.0%
Neoplasms 2540 (1876-3348) 4483 (3324-5861) 76.5% 48 (35-63) 65(48-85) 35.8%
Oesophageal cancer 61(42-86) 75 (49-103) 22.8% 1 (1-2) 1(1-1) −5.5%
Stomach cancer 204 (137-286) 229 (150-323) 12.3% 4(3-5) 3(2-5) −13.6%
Liver cancer 77 (53-104) 140 (96-189) 82.7% 1 (1-2) 2(1-3) 40.6%
Liver cancer secondary to hepatitis B 35 (23-49) 64 (43-89) 81.4% 1 (0-1) 1 (1-1) 39.6%
Liver cancer secondary to hepatitis C 19 (13-27) 34 (23-47) 80.5% <0.5 (0-1) <0.5 (0-1) 38.9%
Liver cancer secondary to alcohol use 15 (9-21) 29 (19-42) 100.2% <0.5 (0-0.5) <0.5 (0-1) 54.1%
Other liver cancer 8(4-12) 12 (7-19) 60.3% <0.5 (0-0.5) <0.5 (0-0.5) 23.3%
Larynx cancer 47 (26-77) 63 (34-102) 32.5% 1 (0-1) 1 (0-1) 2.0%
Trachea, bronchus, and lung cancers 227 (154-317) 355 (234-493) 56.5% 4(3-6) 5 (3-7) 20.5%
Breast cancer 504 (351-714) 898 (623-1268) 78.0% 10 (7-13) 13 (9-18) 37.0%
Cervical cancer 99 (59-146) 111 (64-160) 11.8% 2(1-3) 2(1-2) −14.0%
Uterine cancer 47(25-82) 68 (30-107) 44.5% 1 (0-2) 1 (0-2) 11.2%
Prostate cancer 165 (109-249) 464 (298-729) 181.3% 3(2-5) 7 (4-11) 116.4%
Colon and rectum cancers 307 (223-411) 564 (408-759) 83.9% 6 (4-8) 8(6-11) 41.5%
Mouth cancer 63 (44-84) 101 (71-136) 61.6% 1 (1-2) 1 (1-2) 24.3%
Nasopharynx cancer 15 (9-23) 25 (14-39) 64.1% <0.5 (0-0.5) <0.5 (0-1) 26.3%
Cancer of other part of pharynx and oropharynx 29 (16-42) 45 (25-67) 53.3% 1 (0-1) 1 (0-1) 18.0%
Gallbladder and biliary tract cancer 19 (12-29) 35 (20-53) 81.2% <0.5 (0-1) 1 (0-1) 39.5%
Pancreatic cancer 23 (15-33) 37 (23-54) 59.4% <0.5 (0-1) 1 (0-1) 22.6%
Malignant melanoma of skin 24 (15-40) 45 (25-74) 84.5% <0.5 (0-1) 1 (0-1) 42.0%
Non-melanoma skin cancer 115 (85-148) 255 (192-326) 122.2% 2(2-3) 4(3-5) 71.0%
Ovarian cancer 41 (27-56) 63 (39-89) 53.8% 1 (1-1) 1 (1-1) 18.3%
Testicular cancer 8(4-12) 12 (7-20) 64.2% <0.5 (0-0.5) <0.5 (0-0.5) 26.4%
Kidney and other urinary organ cancers 32 (21-48) 79 (52-118) 143.4% 1 (0-1) 1 (1-2) 87.3%
Bladder cancer 81 (57-110) 125 (85-171) 54.6% 2(1-2) 2(1-2) 18.9%
Brain and nervous system cancers 57 (34-84) 94 (51-134) 63.3% 1 (1-2) 1(1-2) 25.6%
Thyroid cancer 21 (13-32) 48 (28-75) 132.4% <0.5 (0-1) 1 (0-1) 78.8%
Hodgkin's disease 13 (8-20) 17 (10-27) 25.7% <0.5 (0-0.5) <0.5 (0-0.5) −3.3%
Non-Hodgkin's lymphoma 60 (42-80) 110 (77-147) 83.5% 1 (1-2) 2 (1-2) 41.2%
Multiple myeloma 22 (13-34) 36 (21-53) 64.9% <0-5 (0-1) 1 (0-1) 26.9%
Leukaemia 79 (53-110) 123 (83-170) 57.2% 1 (1-2) 2(1-2) 20.9%
Other neoplasms 99 (67-139) 266 (174-366) 168.2% 2(1-3) 4(3-5) 106.4%
Cardiovascular and circulatory diseases 14 373 (11 094-18 134) 21 985 (16 947-27 516) 53.0% 271(209-342) 319 (246-399) 17.7%
Rheumatic heart disease 1150 (765-1709) 1430 (944-2067) 24.3% 22 (14-32) 21 (14-30) −4.4%
Valvular disease due to rheumatic heart disease 861 (477-1429) 1009 (557-1646) 17.3% 16 (9-27) 15 (8-24) −9.8%
Heart failure due to rheumatic heart disease 290 (191-412) 420 (278-592) 45.1% 5 (4-8) 6 (4-9) 11.6%
Ischaemic heart disease 5952 (3679-8768) 8795 (5447-12 806) 47.8% 112 (69-165) 128 (79-186) 13.7%
Myocardial infarction due to ischaemic heart disease 29 (15-45) 42 (22-67) 45.5% 1 (0-1) 1 (0-1) 11.9%
Angina due to ischaemic heart disease 5030 (2942-7567) 7234 (4232-10 986) 43.8% 95 (55-143) 105 (61-159) 10.7%
Heart failure due to ischaemic heart disease 894 (609-1236) 1518 (1038-2128) 69.9% 17 (11-23) 22 (15-31) 30.8%
Cerebrovascular disease 2328 (1864-2837) 4346 (3476-5298) 86.7% 44 (35-54) 63 (50-77) 43.6%
Ischaemic stroke 1857 (1489-2263) 3384 (2705-4121) 82.2% 35 (28-43) 49 (39-60) 40.2%
Ischaemic stroke (acute) 77 (52-107) 133 (90-183) 72.8% 1(1-2) 2 (1-3) 32.9%
Ischaemic stroke (chronic) 1780 (1416-2187) 3251 (2583-3999) 82.6% 34 (27-41) 47 (37-58) 40.5%
Haemorrhagic and other non-ischaemic stroke 471(373-585) 961 (769-1178) 104.1% 9 (7-11) 14 (11-17) 57.0%
Haemorrhagic non-ischaemic stroke (acute) 28 (18-38) 56 (37-78) 104.1% 1 (0-1) 1 (1-1) 57.1%
Haemorrhagic non-ischaemic stroke (chronic) 444 (345-558) 905 (717-1121) 104.1% 8 (7-11) 13 (10-16) 57.0%
Hypertensive heart disease 292 (202-412) 460 (315-639) 57.4% 6 (4-8) 7 (5-9) 21.1%
Cardiomyopathy and myocarditis 272 (183-378) 394 (269-551) 44.8% 5 (3-7) 6 (4-8) 11.4%
Acute myocarditis 1 (0-1) 1 (0-1) 30.9% <0.5 (0-0.5) <0.5 (0-0.5) 0.7%
Heart failure due to cardiomyopathy and myocarditis 271 (182-378) 393 (268-551) 44.8% 5 (3-7) 6 (4-8) 11.4%
Atrial fibrillation and flutter 1433 (970-1987) 2425 (1631-3382) 69.2% 27 (18-37) 35 (24-49) 30.2%
Peripheral vascular disease 256 (132-453) 419 (218-744) 63.7% 5 (2-9) 6 (3-11) 26.0%
Endocarditis 42 (28-60) 62 (42-87) 46.1% 1 (1-1) 1 (1-1) 12.4%
Endocarditis <0.5 (0-1) 1 (0-1) 87.7% <0.5 (0-0.5) <0.5 (0-0.5) 44.4%
Heart failure due to endocarditis 42 (28-59) 61 (42-87) 45.8% 1 (1-1) 1 (1-1) 12.2%
Other cardiovascular and circulatory diseases 2646 (1448-4148) 3655(2053-5581) 38.1% 50 (27-78) 53 (30-81) 6.3%
Heart failure due to other circulatory diseases 183 (123-259) 268 (180-372) 46.3% 3 (2-5) 4 (3-5) 12.6%
Other cardiovascular and circulatory diseases 2463 (1271-3992) 3388 (1783-5346) 37.5% 46 (24-75) 49 (26-78) 5.8%
Chronic respiratory diseases 34 976 (24 536-47 579) 49 303 (33 874-67 087) 41.0% 660 (463-897) 716 (492-974) 8.5%
Chronic obstructive pulmonary disease 20 097 (13 793-28 248) 29 373 (19 850-41 822) 46.2% 379 (260-533) 426 (288-607) 12.5%
Chronic obstructive pulmonary disease 19 805 (13 571-27 835) 28 893 (19 455-41 183) 45.9% 374 (256-525) 419 (282-598) 12.3%
Heart failure due to chronic obstructive pulmonary disease 292 (195-410) 480 (316-678) 64.1% 6 (4-8) 7 (5-10) 26.3%
Pneumoconiosis 212 (104-477) 445 (193-1377) 109.9% 4(2-9) 6(3-20) 61.5%
Silicosis 76 (22-199) 136 (38-408) 79.8% 1 (0-4) 2 (1-6) 38.3%
Asbestosis 44 (4-253) 130(8-974) 192.4% 1(0-5) 2 (0-14) 125.0%
Coal workers' pneumoconiosis 24 (10-43) 33 (13-64) 41.1% <0.5 (0-1) <0.5 (0-1) 8.6%
Other pneumoconiosis 43 (12-108) 101 (26-261) 135.2% 1(0-2) 1 (0-4) 80.9%
Heart failure due to pneumoconiosis 25 (17-36) 45 (31-63) 77.1% <0.5 (0-1) 1 (0-1) 36.3%
Asthma 10 835 (7247-15 268) 13 835 (9286-19 487) 27.7% 204 (137-288) 201 (135-283) −1.7%
Interstitial lung disease and pulmonary sarcoidosis 111 (68-182) 162 (99-268) 45.8% 2(1-3) 2 (1-4) 12.2%
Interstitial lung disease and pulmonary sarcoidosis 69 (37-134) 99 (52-191) 44.6% 1(1-3) 1 (1-3) 11.3%
Heart failure due to interstitial lung disease and pulmonary sarcoidosis 42 (28-60) 62 (42-90) 47.9% 1 (1-1) 1 (1-1) 13.8%
Other chronic respiratory diseases 3722 (2529-5177) 5488 (3773-7675) 47.5% 70 (48-98) 80 (55-111) 13.5%
Cirrhosis of the liver 455 (309-630) 613 (415-862) 34.8% 9 (6-12) 9(6-13) 3.7%
Cirrhosis of the liver secondary to hepatitis B 156 (93-235) 198 (120-298) 26.7% 3 (2-4) 3 (2-4) −2.5%
Cirrhosis of the liver secondary to hepatitis C 113 (67-170) 155(93-235) 37.5% 2 (1-3) 2(1-3) 5.8%
Cirrhosis of the liver secondary to alcohol use 109 (65-163) 160 (94-241) 46.6% 2 (1-3) 2(1-3) 12.8%
Other cirrhosis of the liver 77(46-118) 101 (61-150) 30.2% 1(1-2) 1 (1-2) 0.2%
Digestive diseases (except cirrhosis) 4467 (3265-5979) 5473 (3916-7380) 22.5% 84 (62-113) 79 (57-107) −5.7%
Peptic ulcer disease 355 (224-570) 311 (196-485) −12.3% 7 (4-11) 5 (3-7) −32.5%
Peptic ulcer disease 190 (111-328) 154 (93-254) −18.8% 4(2-6) 2 (1-4) −37.5%
Anaemia due to peptic ulcer disease 165(89-325) 157 (87-273) −4.8% 3(2-6) 2 (1-4) −26.7%
Gastritis and duodenitis 820 (498-1253) 855 (525-1386) 4.2% 15 (9-24) 12 (8-20) −19.8%
Gastritis and duodenitis 178 (120-259) 182 (121-264) 2.3% 3(2-5) 3 (2-4) −21.3%
Anaemia due to gastritis and duodenitis 642 (368-1046) 673 (389-1174) 4.7% 12 (7-20) 10(6-17) −19.4%
Appendicitis 154 (99-226) 176 (112-257) 14.3% 3 (2-4) 3 (2-4) −12.0%
Paralytic ileus and intestinal obstruction without hernia 10 (4-24) 12 (6-27) 24.4% <0.5 (0-0.5) <0.5 (0-0.5) −4.2%
Inguinal or femoral hernia 333 (144-689) 441 (189-861) 32.5% 6(3-13) 6(3-12) 1.9%
Non-infective inflammatory bowel disease 1582 (1130-2151) 1795 (1272-2460) 13.5% 30 (21-41) 26 (18-36) −12.7%
Non-infective inflammatory bowel disease due to ulcerative colitis 932 (583-1492) 1169 (734-1801) 25.4% 18 (11-28) 17 (11-26) −3.5%
Non-infective inflammatory bowel disease due to Crohn's disease 541 (356-775) 513 (334-733) −5.2% 10 (7-15) 7 (5-11) −27.0%
Non-infective inflammatory bowel disease severe episodes due to ulcerative colitis 54 (32-89) 64 (39-102) 18.6% 1 (1-2) 1(1-1) −8.7%
Non-infective inflammatory bowel disease severe episodes due to Crohn's disease 54 (31-91) 50 (30-81) −8.5% 1 (1-2) 1 (0-1) −29.6%
Vascular disorders of intestine 6 (4-10) 14 (8-20) 121.6% <0.5 (0-0.5) <0.5 (0-0.5) 70.5%
Gallbladder and bile duct disease 314 (215-440) 453 (310-635) 44.6% 6 (4-8) 7 (4-9) 11.2%
Pancreatitis 133 (85-198) 206 (131-303) 54.9% 3 (2-4) 3 (2-4) 19.2%
Other digestive diseases 761 (553-1025) 1209 (852-1638) 58.9% 14 (10-19) 18 (12-24) 22.3%
Neurological disorders 29 389 (23 635-35 837) 42 943 (34 605-52 115) 46.1% 554(446-676) 623(502-756) 12.4%
Alzheimer's disease and other dementias 3785 (2720-5007) 6801 (4898-9043) 79.7% 71 (51-94) 99 (71-131) 38.3%
Parkinson's disease 356 (231-560) 606 (396-964) 70.5% 7 (4-11) 9(6-14) 31.2%
Epilepsy 6415 (4993-7799) 8740 (6762-10 594) 36.2% 121 (94-147) 127 (98-154) 4.8%
Multiple sclerosis 373 (276-473) 524 (379-660) 40.8% 7 (5-9) 8 (5-10) 8.3%
Migraine 15 927 (10 394-22 023) 22 362 (14 395-31 121) 40.4% 300 (196-415) 325(209-452) 8.0%
Tension-type headache 1266 (754-2016) 1779 (1056-2822) 40.5% 24 (14-38) 26 (15-41) 8.1%
Other neurological disorders 1267 (958-1616) 2129 (1619-2723) 68.0% 24 (18-30) 31(23-40) 29.3%
Other neurological disorders 1399 (1056-1789) 2353 (1785-3011) 68.2% 26 (20-34) 34 (26-44) 29.4%
Guillain-Barre syndrome due to other neurological disorders 2 (1-3) 3 (2-4) 35.6% <0.5 (0-0.5) <0.5 (0-0.5) 4.4%
Mental and behavioural disorders 129 377 (106 771-154 032) 176 626 (145 613-209 122) 36.5% 2440 (2014-2905) 2564 (2113-3035) 5.0%
Schizophrenia 9760 (6186-13 369) 14 400 (9160-19 752) 47.5% 184 (117-252) 209 (133-287) 13.5%
Alcohol use disorders 10 470 (7173-14 644) 13 826 (9248-19 212) 32.1% 197 (135-276) 201 (134-279) 1.6%
Alcohol dependence 10 385 (7086-14 556) 13 735 (9164-19 108) 32.3% 196 (134-275) 199 (133-277) 1.8%
Fetal alcohol syndrome 85 (49-133) 91 (55-138) 6.9% 2(1-3) 1 (1-2) −17.7%
Drug use disorders 11 764 (8388-15 468) 16 412 (11 836-21 583) 39.5% 222 (158-292) 238 (172-313) 7.3%
Opioid use disorders 4812 (3350-6281) 7170 (5143-9257) 49.0% 91 (63-118) 104 (75-134) 14.6%
Cocaine use disorders 800 (475-1214) 1085 (633-1639) 35.7% 15 (9-23) 16 (9-24) 4.4%
Amphetamine use disorders 1894 (1067-2955) 2596 (1460-3957) 37.1% 36 (20-56) 38 (21-57) 5.5%
Cannabis use disorders 1693 (1105-2418) 2057 (1348-2929) 21.5% 32 (21-46) 30 (20-43) −6.5%
Other drug use disorders 2565 (1583-3817) 3503 (2108-5170) 36.6% 48 (30-72) 51 (31-75) 5.1%
Unipolar depressive disorders 54 010 (40 381-68 450) 74 264 (55 670-94 240) 37.5% 1019 (762-1291) 1078 (808-1368) 5.8%
Major depressive disorder 46 139 (34 517-58 427) 63 179 (47 779-80 891) 36.9% 870 (651-1102) 917 (693-1174) 5.4%
Dysthymia 7871 (5266-10 858) 11 084 (7297-15 447) 40.8% 148 (99-205) 161 (106-224) 8.4%
Bipolar affective disorder 9129 (5757-13 169) 12 867 (8084-18 654) 40.9% 172 (109-248) 187 (117-271) 8.5%
Anxiety disorders 19 664 (13 868-26 820) 26 826 (18 779-36 795) 36.4% 371(262-506) 389 (273-534) 5.0%
Eating disorders 1120 (749-1554) 1956 (1316-2742) 74.6% 21 (14-29) 28 (19-40) 34.3%
Anorexia nervosa 95 (65-136) 188 (125-265) 97.1% 2(1-3) 3 (2-4) 51.7%
Bulimia nervosa 1025 (687-1417) 1768 (1183-2480) 72.5% 19 (13-27) 26 (17-36) 32.7%
Pervasive development disorders 5918 (4133-8130) 7666 (5355-10 565) 29.5% 112 (78-153) 111 (78-153) −0.3%
Autism 3088 (2119-4260) 4007 (2752-5563) 29.8% 58 (40-80) 58 (40-81) −0.2%
Asperger's syndrome 2830 (1917-4016) 3659 (2463-5150) 29.3% 53 (36-76) 53 (36-75) −0.5%
Childhood behavioural disorders 5472 (3277-8359) 6245 (3785-9347) 14.1% 103 (62-158) 91 (55-136) −12.2%
Attention-deficit hyperactivity disorder 424 (244-667) 491(280-775) 15.8% 8 (5-13) 7 (4-11) −10.9%
Conduct disorder 5047 (2960-7840) 5753 (3428-8748) 14.0% 95 (56-148) 84 (50-127) −12.3%
Idiopathic intellectual disability 1247 (746-1924) 1043 (572-1687) −16.4% 24 (14-36) 15 (8-24) −35.7%
Other mental and behavioural disorders 822 (485-1307) 1121 (661-1774) 36.4% 16 (9-25) 16 (10-26) 5.0%
Diabetes, urogenital, blood, and endocrine diseases 38 626 (28 236-51 159) 56 924 (42 172-75 399) 47.4% 729 (533-965) 826 (612-1094) 13.4%
Diabetes mellitus 12 412 (8403-17 524) 20 758 (14 415-28 762) 67.2% 234 (158-331) 301 (209-417) 28.7%
Uncomplicated diabetes mellitus 4260 (2420-6828) 6569 (3684-10 380) 54.2% 80 (46-129) 95 (53-151) 18.7%
Diabetic foot 209 (108-356) 308 (160-518) 47.1% 4 (2-7) 4(2-8) 13.2%
Diabetic neuropathy 7325 (4967-10 520) 11 914 (7977-17 035) 62.6% 138 (94-198) 173 (116-247) 25.2%
Amputation due to diabetes mellitus 392 (192-669) 905 (481-1427) 130.9% 7 (4-13) 13 (7-21) 77.6%
Vision loss due to diabetes mellitus 227 (166-307) 1062 (795-1395) 368.6% 4 (3-6) 15 (12-20) 260.6%
Acute glomerulonephritis 1 (0-2) 1 (0-2) 1.6% <0.5 (0-0.5) <0.5 (0-0.5) −21.8%
Chronic kidney diseases 2558 (1900-3288) 4018 (2972-5204) 57.1% 48 (36-62) 58 (43-76) 20.9%
Chronic kidney disease due to diabetes mellitus 621 (453-796) 1003 (740-1317) 61.5% 12 (9-15) 15 (11-19) 24.2%
Stage IV chronic kidney disease due to diabetes mellitus 88 (58-126) 141 (94-205) 60.5% 2(1-2) 2(1-3) 23.5%
End-stage renal disease due to diabetes mellitus 388 (270-506) 626 (436-817) 61.5% 7 (5-10) 9(6-12) 24.2%
Anaemia due to chronic kidney disease stage III from diabetes mellitus 145 (79-237) 235 (126-378) 62.0% 3 (1-4) 3(2-5) 24.7%
Chronic kidney disease due to hypertension 550 (411-711) 872 (645-1123) 58.4% 10 (8-13) 13 (9-16) 21.9%
Stage IV chronic kidney disease due to hypertension 88 (59-128) 138 (93-198) 56.7% 2(1-2) 2(1-3) 20.6%
End-stage renal disease due to hypertension 326 (225-422) 515(359-670) 58.0% 6 (4-8) 7(5-10) 21.6%
Anaemia due to chronic kidney disease stage III from hypertension 136 (77-222) 219 (124-354) 60.6% 3 (1-4) 3(2-5) 23.6%
Chronic kidney disease unspecified 1386 (1032-1800) 2143(1585-2779) 54.6% 26 (19-34) 31(23-40) 19.0%
Stage IV unspecified or other chronic kidney disease 229 (154-335) 352 (233-506) 53.9% 4(3-6) 5 (3-7) 18.4%
End-stage renal disease from unspecified or other chronic kidney disease 799 (555-1042) 1242 (872-1607) 55.5% 15 (10-20) 18 (13-23) 19.6%
Anaemia due to unspecified or other chronic kidney disease stage III 359 (208-579) 549 (314-889) 53.1% 7 (4-11) 8(5-13) 17.8%
Urinary diseases and male infertility 4651 (3057-7025) 8188 (5398-11 978) 76.0% 88 (58-133) 119 (78-174) 35.5%
Tubulointerstitial nephritis, pyelonephritis, and urinary tract infections 156 (84-269) 207 (109-360) 33.2% 3 (2-5) 3(2-5) 2.5%
Urolithiasis 480 (306-842) 716 (447-1425) 49.1% 9 (6-16) 10 (6-21) 14.7%
Urolithiasis episodes 204 (107-526) 225 (104-918) 10.5% 4 (2-10) 3(2-13) −15.0%
Chronic urolithiasis 277 (156-443) 491(276-785) 77.5% 5 (3-8) 7 (4-11) 36.6%
Benign prostatic hyperplasia 3726 (2392-5645) 6834 (4377-10 179) 83.4% 70 (45-106) 99 (64-148) 41.1%
Male infertility 126 (50-270) 173 (70-365) 36.9% 2 (1-5) 3(1-5) 5.3%
Other urinary diseases 162 (103-267) 258 (167-415) 58.8% 3 (2-5) 4(2-6) 22.2%
Gynaecological diseases 7671(4880-11715) 10 042(6226-15619) 30.9% 145 (92-221) 146 (90-227) 0.7%
Uterine fibroids 2341 (1568-3340) 3037 (1967-4551) 29.7% 44 (30-63) 44 (29-66) −0.2%
Uterine fibroids 934 (401-1852) 1527(664-3059) 63.5% 18 (8-35) 22 (10-44) 25.8%
Anaemia due to uterine fibroids 1407 (943-2023) 1509 (1000-2199) 7.3% 27 (18-38) 22 (15-32) −17.4%
Polycystic ovarian syndrome 2027 (971-3786) 2756 (1312-5212) 35.9% 38 (18-71) 40 (19-76) 4.6%
Polycystic ovarian syndrome 1982 (931-3747) 2694 (1245-5171) 35.9% 37 (18-71) 39 (18-75) 4.6%
Infertility due to polycystic ovarian syndrome 45 (18-95) 62 (25-128) 37.5% 1(0-2) 1 (0-2) 5.8%
Female infertility 91 (36-189) 125 (50-259) 37.6% 2 (1-4) 2 (1-4) 5.9%
Endometriosis 404 (142-738) 544 (188-1007) 34.6% 8 (3-14) 8(3-15) 3.5%
Endometriosis 388 (129-715) 522 (166-974) 34.4% 7 (2-13) 8(2-14) 3.4%
Infertility due to endometriosis 16(6-35) 22 (9-46) 37.8% <0.5 (0-1) <0.5 (0-1) 6.0%
Genital prolapse 1339 (544-2686) 1811 (741-3649) 35.2% 25 (10-51) 26 (11-53) 4.1%
Premenstrual syndrome 983 (49-2592) 1249 (63-3337) 27.0% 19 (1-49) 18 (1-48) −2.3%
Other gynaecological diseases 485 (330-703) 520 (345-759) 7.3% 9(6-13) 8 (5-11) −17.4%
Haemoglobinopathies and haemolytic anaemias 8271 (5746-11276) 10 197 (7166-13 843) 23.3% 156 (108-213) 148 (104-201) −5.1%
Thalassaemias 3725 (2499-5279) 4636 (3098-6621) 24.4% 70 (47-100) 67(45-96) −4.2%
β-thalassaemia major 31 (17-56) 33 (19-59) 7.9% 1 (0-1) <0.5 (0-1) −16.9%
Haemoglobin E/β-thalassaemia 22 (14-34) 24 (15-37) 8.8% <0.5 (0-1) <0.5 (0-1) −16.3%
Haemoglobin H/β-thalassaemia 10 (6-16) 10 (6-16) 3.7% <0.5 (0-0.5) <0.5 (0-0.5) −20.2%
Anaemia due to thalassaemias 3653 (2427-5219) 4557(3024-6530) 24.7% 69 (46-98) 66 (44-95) −4.0%
Heart failure due to thalassaemias 10 (6-14) 13 (8-19) 34.1% <0.5 (0-0.5) <0.5 (0-0.5) 3.2%
Sickle cell disorders 2647 (1829-3615) 3665 (2612-4949) 38.5% 50 (34-68) 53 (38-72) 6.5%
Homozygous sickle cell and severe sickle cell/β-thalassaemia 334 (238-441) 546 (389-736) 63.8% 6 (4-8) 8(6-11) 26.1%
Haemoglobin sickle cell disorders 78 (54-107) 130 (88-182) 65.5% 1 (1-2) 2(1-3) 27.3%
Mild sickle cell/β-thalassaemia 26 (18-37) 38 (27-53) 43.8% <0.5 (0-1) 1 (0-1) 10.6%
Anaemia due to sickle cell disorders 2211 (1439-3181) 2954 (1957-4240) 33.6% 42 (27-60) 43 (28-62) 2.8%
G6PD deficiency 120 (81-174) 146 (97-210) 22.1% 2(2-3) 2(1-3) −6.1%
Anaemia due to G6PD deficiency 116 (77-171) 141(93-205) 21.5% 2(1-3) 2(1-3) −6.5%
Heart failure due to G6PD deficiency 4 (2-6) 5(3-8) 40.2% <0.5 (0-0.5) <0.5 (0-0.5) 7.8%
Other haemoglobinopathies and haemolytic anaemias 1779 (1193-2565) 1750 (1171-2503) −1.6% 34 (23-48) 25 (17-36) −24.3%
Anaemia due to other haemoglobinopathies and haemolytic anaemias 1757 (1173-2545) 1720 (1138-2483) −2.1% 33 (22-48) 25 (17-36) −24.7%
Heart failure due to other haemoglobinopathies and haemolytic anaemias 22 (14-32) 31(20-45) 39.5% <0.5 (0-1) <0.5 (0-1) 7.4%
Other endocrine, nutritional, blood, and immune disorders 3063 (2256-4177) 3721 (2713-5114) 21.5% 58 (43-79) 54 (39-74) −6.5%
Other endocrine, nutritional, blood, and immune disorders 1254 (739-1952) 1919 (1133-2991) 53.0% 24 (14-37) 28 (16-43) 17.7%
Anaemia due to other endocrine, nutritional, blood, and immune disorders 1777 (1187-2562) 1756 (1166-2542) −1.2% 34 (22-48) 25 (17-37) −23.9%
Heart failure due to other endocrine, nutritional, blood, and immune disorders 33 (22-47) 48 (33-69) 46.1% 1 (0-1) 1 (0-1) 12.4%
Musculoskeletal disorders 114 719 (87 053-145 247) 165 955 (126 364-208 779) 44.7% 2164 (1642-2740) 2409 (1834-3030) 11.3%
Rheumatoid arthritis 2566 (1831-3381) 3776 (2672-4954) 47.1% 48 (35-64) 55(39-72) 13.2%
Osteoarthritis 10 449 (7100-14 788) 17 135 (11 884-24 256) 64.0% 197 (134-279) 249 (172-352) 26.2%
Osteoarthritis of the hip 1821 (1200-2616) 2917 (1945-4389) 60.2% 34 (23-49) 42 (28-64) 23.2%
Osteoarthritis of the knee 8627 (5929-12 276) 14 218 (9809-19 968) 64.8% 163 (112-232) 206 (142-290) 26.8%
Low back and neck pain 82 111 (56 962-110 433) 116 704 (80 615-156 527) 42.1% 1549 (1074-2083) 1694 (1170-2272) 9.4%
Low back pain 58 245 (39 934-78 139) 83 063 (56 632-111 880) 42.6% 1099 (753-1474) 1206 (822-1624) 9.7%
Neck pain 23 866 (16 535-33 105) 33 640 (23 469-46 476) 41.0% 450 (312-624) 488 (341-675) 8.5%
Gout 76 (48-112) 114 (72-167) 49.3% 1 (1-2) 2(1-2) 14.9%
Other musculoskeletal disorders 19 517 (16 148-22 127) 28 226 (23 201-31 884) 44.6% 368 (305-417) 410 (337-463) 11.3%
Other non-communicable diseases 66 478 (45 586-97 937) 86 771 (59 561-128 605) 30.5% 1254 (860-1847) 1259 (864-1867) 0.4%
Congenital anomalies 2620(2088-3333) 3279 (2594-4167) 25.2% 49 (39-63) 48 (38-60) −3.7%
Neural tube defects 569 (330-901) 754 (439-1142) 32.6% 11 (6-17) 11 (6-17) 2.0%
Congenital heart anomalies 498 (350-711) 563 (388-804) 13.0% 9 (7-13) 8(6-12) −13.0%
Congenital heart anomalies 189 (86-354) 226 (103-425) 19.1% 4 (2-7) 3 (1-6) −8.3%
Heart failure due to congenital heart anomalies 308 (203-442) 337 (221-486) 9.3% 6 (4-8) 5 (3-7) −15.9%
Ccenter lip and ccenter palate 259 (180-362) 254 (181-346) −1.7% 5 (3-7) 4(3-5) −24.4%
Down's syndrome 462 (306-664) 627 (425-888) 35.7% 9(6-13) 9(6-13) 4.4%
Other chromosomal abnormalities 191 (127-274) 276 (182-392) 44.1% 4(2-5) 4(3-6) 10.8%
Turner syndrome 3 (1-6) 4(2-8) 35.6% <0.5 (0-0.5) <0.5 (0-0.5) 4.3%
Klinefelter syndrome 5 (2-10) 6 (3-14) 38.7% <0.5 (0-0.5) <0.5 (0-0.5) 6.8%
Chromosomal unbalanced rearrangements 184 (123-261) 265 (176-377) 44.3% 3(2-5) 4 (3-5) 11.1%
Other congenital anomalies 642 (464-868) 806 (596-1053) 25.6% 12 (9-16) 12 (9-15) −3.3%
Other congenital anomalies 437 (325-580) 595 (446-775) 36.4% 8 (6-11) 9 (6-11) 4.9%
Hearing loss due to other congenital anomalies 225 (142-336) 240 (152-363) 6.6% 4 (3-6) 3 (2-5) −17.9%
Skin and subcutaneous diseases 26 273 (16 798-40 932) 33 744 (21 503-52 280) 28.4% 496 (317-772) 490 (312-759) −1.2%
Eczema 6890 (3508-10 872) 8897 (4518-14 049) 29.1% 130 (66-205) 129 (66-204) −0.6%
Psoriasis 742 (371-1179) 1059 (528-1690) 42.8% 14 (7-22) 15 (8-25) 9.8%
Cellulitis 302 (126-648) 376 (163-831) 24.5% 6 (2-12) 5(2-12) −4.2%
Abscess, impetigo, and other bacterial skin diseases 1038 (473-2016) 1322 (599-2511) 27.4% 20(9-38) 19 (9-36) −1.9%
Impetigo 871 (417-1624) 1088 (514-2048) 24.9% 16 (8-31) 16 (7-30) −3.9%
Abscess and other bacterial skin diseases cases 167 (54-386) 235 (78-539) 40.8% 3 (1-7) 3(1-8) 8.3%
Scabies 1881 (956-3384) 1580 (807-2792) −16.0% 35 (18-64) 23 (12-41) −35.4%
Fungal skin diseases 1618 (532-3754) 2303 (740-5435) 42.3% 31 (10-71) 33 (11-79) 9.5%
Viral skin diseases 2354(1058-4369) 2731(1203-4941) 16.0% 44 (20-82) 40 (17-72) −10.7%
Molluscum contagiosum 289 (88-702) 270(85-645) −6.6% 5(2-13) 4 (1-9) −28.1%
Viral warts 2065 (816-3960) 2461 (984-4720) 19.2% 39 (15-75) 36 (14-69) −8.3%
Acne vulgaris 3281 (1545-6205) 4002 (1869-7575) 22.0% 62 (29-117) 58 (27-110) −6.2%
Alopecia areata 1002 (313-1906) 1352 (424-2567) 35.0% 19 (6-36) 20 (6-37) 3.9%
Pruritus 1433 (682-2676) 2086 (1004-3951) 45.6% 27 (13-50) 30 (15-57) 12.1%
Urticaria 1968 (757-3431) 2600 (980-4441) 32.1% 37 (14-65) 38 (14-64) 1.6%
Decubitus ulcer 320 (165-524) 476 (237-779) 48.8% 6 (3-10) 7 (3-11) 14.5%
Other skin and subcutaneous diseases 3445 (1638-6437) 4961 (2324-9239) 44.0% 65 (31-121) 72 (34-134) 10.8%
Sense organ diseases 25 169 (18 140-35 220) 34 733 (25 167-47 663) 38.0% 475 (342-664) 504 (365-692) 6.2%
Glaucoma 443 (338-561) 943 (725-1178) 112.7% 8(6-11) 14 (11-17) 63.7%
Cataracts 4225 (3283-5364) 4732 (3647-6010) 12.0% 80 (62-101) 69 (53-87) −13.8%
Macular degeneration 513 (388-647) 1329 (1026-1668) 158.9% 10 (7-12) 19 (15-24) 99.2%
Refraction and accommodation disorders 3608 (2688-4762) 5593 (4117-7468) 55.0% 68 (51-90) 81 (60-108) 19.3%
Other hearing loss 12 211 (7258-19 495) 15 761 (9455-25 210) 29.1% 230 (137-368) 229 (137-366) −0.7%
Other vision loss 4069 (2171-7180) 6240(3260-11208) 53.4% 77 (41-135) 91(47-163) 18.0%
Other sense organ diseases 100 (34-231) 136 (46-309) 35.4% 2 (1-4) 2 (1-4) 4.2%
Oral disorders 12 417 (6824-20 984) 15 015 (7795-26 482) 20.9% 234 (129-396) 218 (113-384) −7.0%
Dental caries 3704 (1523-7150) 4984(2086-9356) 34.5% 70 (29-135) 72 (30-136) 3.5%
Dental caries of baby teeth 403 (164-774) 425 (172-818) 5.7% 8 (3-15) 6(3-12) −18.7%
Dental caries of permanent teeth 3302 (1347-6455) 4559 (1907-8554) 38.1% 62 (25-122) 66 (28-124) 6.2%
Periodontal disease 3440 (1310-7305) 5410 (2051-11 286) 57.3% 65 (25-138) 79 (30-164) 21.0%
Edentulism 5273 (3100-8127) 4621 (2678-7296) −12.4% 99 (58-153) 67 (39-106) −32.6%
Injuries 34 068 (24 209-47 034) 47162 (32 958-66 050) 38.4% 643 (457-887) 685 (478-959) 6.5%
Transport injuries 12062 (8524-16826) 16 268 (11 304-22 717) 34.9% 228 (161-317) 236 (164-330) 3.8%
Road injury 10 363 (7315-14 487) 13 485 (9362-18 950) 30.1% 195 (138-273) 196 (136-275) 0.1%
Pedestrian injury by road vehicle 3106 (2183-4360) 4520 (3139-6367) 45.6% 59 (41-82) 66(46-92) 12.0%
Pedal cycle vehicle 755 (536-1056) 1025 (714-1436) 35.7% 14 (10-20) 15 (10-21) 4.4%
Motorised vehicle with two wheels 1750 (1234-2435) 2224 (1529-3133) 27.1% 33 (23-46) 32 (22-45) −2.2%
Motorised vehicle with three or more wheels 4138 (2901-5793) 5792 (4041-8114) 40.0% 78 (55-109) 84 (59-118) 7.7%
Road injury other 1440 (1 013-2 020) 1196 (824-1673) −16.9% 27 (19-38) 17 (12-24) −36.1%
Other transport injury 1699 (1184-2386) 2783 (1902-3872) 63.8% 32(22-45) 40(28-56) 26.0%
Unintentional injuries other than transport injuries 19 036 (13 233-26 794) 26 620 (18 472-37 641) 39.8% 359 (250-505) 386 (268-546) 7.6%
Falls 13 324 (9110-18 725) 19 459 (13 559-27 481) 46.0% 251(172-353) 282 (197-399) 12.4%
Drowning 233 (161-326) 281 (191-391) 20.9% 4 (3-6) 4(3-6) −7.0%
Fire, heat, and hot substances 1010 (637-1575) 1398 (857-2232) 38.4% 19 (12-30) 20 (12-32) 6.5%
Poisonings 323(210-470) 417(276-621) 29.3% 6 (4-9) 6(4-9) −0.5%
Exposure to mechanical forces 922 (599-1387) 1021 (662-1490) 10.8% 17 (11-26) 15 (10-22) −14.7%
Mechanical forces (firearm) 526 (346-784) 467 (305-676) −11.2% 10 (7-15) 7(4-10) −31.7%
Mechanical forces (other) 710 (460-1074) 910 (588-1336) 28.2% 13 (9-20) 13(9-19) −1.3%
Adverse effects of medical treatment 585 (401-824) 1088 (727-1537) 85.9% 11 (8-16) 16 (11-22) 43.1%
Animal contact 437 (293-634) 234 (154-329) −46.4% 8 (6-12) 3(2-5) −58.7%
Animal contact (venomous) 355 (233-526) 168 (110-242) −52.5% 7 (4-10) 2 (2-4) −63.4%
Animal contact (non-venomous) 82 (55-119) 66 (44-93) −20.0% 2(1-2) 1 (1-1) −38.4%
Unintentional injuries not classified elsewhere 2202 (1484-3108) 2720 (1866-3827) 23.5% 42 (28-59) 39 (27-56) −4.9%
Self-harm and interpersonal violence 1571(1066-2188) 1985 (1366-2726) 26.4% 30 (20-41) 29 (20-40) −2.8%
Self-harm 308 (209-428) 407 (278-577) 32.3% 6 (4-8) 6 (4-8) 1.8%
Interpersonal violence 1263 (840-1775) 1578 (1085-2180) 24.9% 24 (16-33) 23(16-32) −3.9%
Assault by firearm 504 (336-714) 587(404-808) 16.5% 10 (6-13) 9(6-12) −10.4%
Assault by sharp object 368 (245-516) 540 (369-743) 46.8% 7(5-10) 8 (5-11) 12.9%
Assault by other means 543(362-758) 678 (464-940) 25.0% 10 (7-14) 10 (7-14) −3.9%
Forces of nature, war, and legal intervention 1399 (903-2080) 2289 (1550-3341) 63.6% 26 (17-39) 33 (22-48) 25.9%
Exposure to forces of nature 173 (110-269) 2187 (1480-3210) 1164.7% 3(2-5) 32 (21-47) 873.1%
Collective violence and legal intervention 1226 (779-1854) 102 (66-153) −91.7% 23 (15-35) 1 (1-2) −93.6%

Data are YLDs (95% uncertainty interval) or percentage change (%A). G6PD=glucose-6-phosphate dehydrogenase deficiency. Ecoli=Escherichia coli. H influenzae=Haemophilus influenzae. S pneumoniae=Streptococcus pneumoniae.