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. Author manuscript; available in PMC: 2019 Jan 29.
Published in final edited form as: Nature. 2018 Jun 13;558(7710):435–439. doi: 10.1038/s41586-018-0218-8

Figure 3 |. SNIPPs exhibit time-dependent cumulative phosphorylation.

Figure 3 |

a, A schematic of time-course sleep-deprivation. b, Volcano plots of SD1/SD0, SD3/SD0, SD6/SD0 phosphoproteome comparisons. Multiple unpaired t-test (p-value) following FDR (q-value) analysis. c, Temporal profile and classification of phospho-state changes of SNIPPs. d, Circadian analysis of absolute NREMS delta power of Vehicle (Veh) or MK801 (MK)-injected mice (n = 14). Mean ± s.e.m., two-way ANOVA, Sidak’s. *(black) P < 0.05; *(cyan) P < 0.01; *(red) P < 0.001. e, Global ∆Ps analysis of MK/Veh group. f, Time-dependent cumulative phosphorylation of 13 SWA-SNIPPs shared by Sleepy, SD and MK models. Synaptic proteins (bold).