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. 2019 Jan 23;15:157–178. doi: 10.2147/TCRM.S147318

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The hypothesis proposed by Barbieri in 1990.

Notes: It postulates the existence of three zones characterized by different levels of circulating estrogens following GnRHSA administration. Zone A, where high levels immediately follow administration of the analog. Zone C, where low levels are induced by the full action of the GnRHSA. Zone B, where some rebound exists following treatment with an add-back therapy. At these intermediate concentrations, only minimal regrowth occurs. Data from Barbieri et al, 1990.65