Table 1.
Expression of HLA class I and class II in HCC tumors from 43 distinct patients and correlation with clinico-pathological findings.
| Cases |
HLA-I Expression |
HLA-II Expression |
||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Total 43 | High (≥ 70%)a |
Medium (20% ≤ x < 70%) |
Low (< 20%) |
p value | Positive 1 1% ≤ x < 3%a |
Negative | p value |
| Gender | ||||||||
| M/F | 35/8 | 18/2 | 13/6 | 4/0 | 6/1 | 29/7 | ||
| Age Mean (years) |
67 ± 11 | 68/67 | 62/70 | 69/0 | 0.370 | 64/73 | 67/69 | 0.573 |
| Grading | 0.582 | 0.311 | ||||||
| G3 | 1 | 2 | 0 | 1 | 2 | |||
| G2 | 17 | 12 | 3 | 6 | 26 | |||
| G1 | 2 | 5 | 1 | 0 | 8 | |||
| Infiltration | 0.586 | 0.137 | ||||||
| 3+ | 2 | 0 | 0 | 1 | 1 | |||
| 2+ | 6 | 6 | 1 | 1 | 12 | |||
| 1+ | 9 | 9 | 1 | 5 | 14 | |||
| 0 | 3 | 4 | 2 | 0 | 9 | |||
| CD8b | 43.5 | 18.8 | 2.5 | 0.040* | 50 | 34.6 | 0.344 | |
| CD4 | 28 | 19.2 | 2.5 | 0.138 | 19.5 | 21.8 | 0.445 | |
| Infection | 0.556 | 0.815 | ||||||
| HCV and/or HBV | 9 | 11 | 1 | 4 | 17 | |||
| No infection | 7 | 3 | 2 | 2 | 10 | |||
| Not documented | 4 | 5 | 1 | 1 | 9 | |||
a percent values (in parenthesis) indicate the number of cells expressing HLA-I or HLA-II molecules
b mean of CD8 or CD4 positive infiltrating cells as obtained by counting the stained cells in at least three representative fields of the corresponding High, Medium and Low HLA class I-expressing cells
*statistically significant with p < 0.05