Figure 6.

Without the silicone sealant to fix the devices in place, electrodes were buried under the meninges by 14 dpi. (a) Representative images tracking the meningeal-electrode interface from the same animal over the first week post-implant (the electrode boundary is outlined in white). By 7 days post implant, the device is almost entirely buried in tissue. (b) For 5 devices implanted in craniotomies without silicone, 100% were completely buried in in tissue by 14 days post-implant. (c) Representative images from 21 dpi to confirm that, after being buried, electrodes are fully underneath meningeal collagen (left panel) and within the underlying cortex (right panel; the electrode is outlined in white). (d) CX3CR1(+) cells adhered to devices explanted at 28dpi from the silicone group (top) are morphologically distinct from those adhered to saline sealed devices (bottom). 2 explants are shown for each condition. All scale bars are 200 µm.