Figure 2.

Experimental melioidosis is associated with thrombocytopenia and effect of anti-GPIbα on platelet counts. Mice were treated with anti-GPIbα (platelet depletion) or immunoglobulin G (IgG) control (both 0.4 µg/g) and infected with Burkholderia pseudomallei via the airway and killed after 24, 48, or 72 hours or killed uninfected (t = 0 hours). A, Platelet counts before (t = 0 hours) and after (t = 24, 48, or 72 hours) infection. B, Representative log-scale scatterplots of CD61-positive platelets in blood of uninfected control and anti–GPIbα-treated mice. Data are represented as bars (median with interquartile range). n = 8 mice per group. *P < .05, ***P < .001 vs IgG control or vs uninfected mice. Abbreviations: FSC-H, forward scatter height; SSC-H, side scatter height.