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. 2018 Oct 11;219(4):648–659. doi: 10.1093/infdis/jiy541

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© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Thrombocytopenia impairs survival and enhances bacterial growth during Burkholderia pseudomallei pneumonia-derived sepsis. Mice were treated with anti-GPIbα (platelet depletion) or immunoglobulin G (IgG) control (both 0.4 µg/g) and infected with B. pseudomallei via the airway and killed after 24, 48, or 72 hours or were observed in a survival experiment. Survival (A) and clinical observation score (B). C, Bacterial quantification of indicated organs. Data are expressed as box-and-whisker plots depicting the smallest observation, lower quartile, median, upper quartile, and largest observation. n = 20 per group for survival experiment and n = 8 mice per group for bacterial quantification. *P < .05, **P < .01, ***P < .001 vs IgG control. Abbreviations: BALF, bronchoalveolar lavage; CFU, colony-forming units.