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. 2019 Jan 29;14(1):e0211268. doi: 10.1371/journal.pone.0211268

Fig 2.

Fig 2

Schematic overview of the workflow used in this study: 1) Screening of Prestwick Chemical Library (PCL) alone and in combination with one of the approved Pt drugs against PANC-1 and A549 cells to identify hit combinations (HCs); 2) Re-testing the PCL compounds identified in HCs during the primary study alone and in combination with the Pt drug to exclude false-positive HCs; 3) HCs studies in dose-response manner and synergy quantification; 4) Secondary assay, based on HCA.