Fig 3. Supervised analysis of signaling, transcription, and extracellular matrix (ECM) factors represented within categories of putative GLI transcriptional targets.

A) The 309 differentially expressed genes (DEG) which mapped onto identified GLI binding regions were separated into 7 bins (a-g) based on binding by GLI1 (G1), and/or GLI2 (G2), and/or both (GIS). B) Candidate genes were selected based on their potential to impact signaling, transcription, and expression of extracellular matrix genes that may have implications for chondrosarcoma pathogenesis.