Fig. 8.

(A) Microarray layout for the identification of the chromosomal rearrangements leading to different types of leukemia. Elements of the biochip with immobilized oligonucleotides specific to the sequences of different chimeric genes are marked in various colors. (B) The hybridization pattern obtained by analyzing an RNA sample containing the PICALM-AF10 fusion transcript that is associated with a poor prognosis. Such type of leukemia requires allogeneic transplantation of hematopoietic stem cells