Physiologic parameters monitored in rice rats during the surgical tolerance period. (A) Isoflurane (blue) resulted in sustained rectal temperature until the end of the procedure, but rectal temperature was significantly decreased under ketamine–dexmedetomidine (orange) and ketamine–xylazine (gray) at the last 2 time points of the surgical tolerance period. (B) SpO2 was within 96% to 99% in all rats with the 3 anesthetics during the complete surgical tolerance stage. (C) Respiratory rate, (D) heart rate, and (E) SBP were consistently stable in rice rats for all 3 anesthesia modalities. However, respiratory and heart rates in ketamine–dexmedetomidine- and ketamine–xylazine-treated rats were lower than those in isoflurane-treated rats. *, Values for isoflurane group (light blue) are significantly (P < 0.05) different from that for the ketamine–dexmedetomidine (orange) or ketamine–xylazine (gray) group. Data were analyzed by using ANOVA.