Figure 3. Effect of the proteasome inhibitors, bortezomib and carfilzomib on the dexrazoxane-induced decrease in Top2β levels in neonatal rat cardiomyocytes. Myocytes were treated with bortezomib (1 μM) or carfilzomib (2 μM) for 30 minutes in growth medium prior to a 6-hour treatment with dexrazoxane (100 μM), lysed and subject to sodium dodecyl sulphate polyacrylamide gel electrophoresis and western blotting. Images reproduced from Hasinoff et al [61] with permission (Springer; Copyright Clearance Licence: 4165441151593).
