Table 3.
Stroke and All-Cause Mortality in Propensity Score–Matched Patients
| Outcome | No LAAO | LAAO | Absolute Rate Difference (95% CI)a | HR (95% CI) | P Valueb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Patients | No. of Events | Person-Years | Event Ratea | No. of Patients | No. of Events | Person-Years | Event Ratea | ||||
| Ischemic Stroke or Systemic Embolism | |||||||||||
| Overall | 4295 | 122 | 7665 | 1.59 | 4295 | 90 | 7908 | 1.14 | 0.45 (0.09 to 0.82) | 0.73 (0.56 to 0.96) | .03 |
| AF at baseline | 3219 | 97 | 5683 | 1.71 | 3219 | 67 | 6032 | 1.11 | 0.60 (0.16 to 1.03) | 0.68 (0.50 to 0.92) | .01 |
| No AF at baseline | 1076 | 25 | 1982 | 1.26 | 1076 | 23 | 1877 | 1.23 | 0.04 (−0.67 to 0.74) | 0.95 (0.54 to 1.68) | .87 |
| Death | |||||||||||
| Overall | 4295 | 335 | 7792 | 4.30 | 4295 | 243 | 8083 | 3.01 | 1.29 (0.70 to 1.89) | 0.71 (0.60 to 0.84) | <.001 |
| AF at baseline | 3219 | 285 | 5782 | 4.93 | 3219 | 199 | 6171 | 3.22 | 1.70 (0.98 to 2.43) | 0.67 (0.56 to 0.80) | <.001 |
| No AF at baseline | 1076 | 50 | 2010 | 2.49 | 1076 | 44 | 1912 | 2.30 | 0.19 (−0.78 to 1.16) | 0.92 (0.61 to 1.37) | .67 |
Abbreviations: AF, atrial fibrillation; LAAO, surgical occlusion of the left atrial appendage.
a
Calculated as the number of events per 100 person-years.
b
The interaction term between prior AF and LAAO was not statistically significant (P = .29 for stroke and P = .16 for mortality).