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. 2018 Dec 10;8(2):e1544442. doi: 10.1080/2162402X.2018.1544442

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — PD-L1, CD3 and CD8 significantly associate with MSI-high and EBV+ samples.

GC tissues were examined for changes in PD-L1 expression and immune prevalence. Shown are (a) PD-L1, CD3 and CD8 in MSI and MSS subgroup, (b) Kaplan-Meier estimates of overall survival (OS) according to PD-L1 TC and MSI stratification, (c) Pie charts depict the frequency of patients with high and low CD8, CD3 and with positive and negative PD-L1 TC densities in MSI and MSS populations. The cut-offs used were PD-L1 TC and IC (≥ 1%), CD3 (500 cells/mm2) and CD8 (600 cells/mm2). Also shown are PD-L1, CD3 and CD8 expression in (d) Lauren subgroups and (e) by EBV status. Data were statistically analysed by Mann-Whitney test (MSI, EBV) or KruskalWallis test (Lauren) (*P < 0.05, **p < 0.01, ***p < 0.001, error bars depict ± 1 s.e, TC; tumour cells, IC; immune cells, MSI; microsatellite instable, MSS; microsatellite stable)