Table 3B.

Univariate and multivariate model analysis.

		Univariate			Multivariate			Univariate		Multivariate
Marker		Median OS	HR	P-value	HR	p-value	Median DFS	HR	P-value	HR	p-value
PD-L1 TC	-ve	48.5 (35.9 - 67.8)	0.387 (0.241 - 0.620)	<0.01	0.394 (0.243 - 0.639)	<0.01	42.5 (25.8 - 60.2)	0.482 (0.298 - 0.776)	<0.01	0.506 (0.311 - 0.824)	<0.01
	+ve	N/C					N/C
PD-L1 IC	-ve	35.9 (19.2 - N/C)	0.766 (0.507 - 1.189)	0.245	0.773 (0.494 - 1.207)	0.258	30.0 (12.0 - N/C)	0.713 (0.456 - 1.118)	0.141	0.665 (0.419 - 1.056)	0.083
	+ve	67.5 (53.0 - 82.2)					59.5 (42.4 - (N/C)
CD3	Low	28.3 (23.4 - 49.8)	0.623 (0.461 - 0.838)	<0.01	0.648 (0.473 - 0.890)	<0.01	15.6 (11.6 - 43.8)	0.629 (0.455 - 0.868)	<0.01	0.665 (0.471 - 0.939)	0.021
	High	71.2 (57.1 - N/C)					60.2 (43.4 - N/C)
CD8	Low	37.9 (30.9 - 59.7)	0.517 (0.358 - 0.746)	<0.01	0.516 (0.347 - 0.770)	<0.01	30.0 (18.6 - 57.2)	0.560 (0.374 - 0.837)	<0.01	0.619 (0.405 - 0.947)	0.027
	High	N/C					79.8 (73.7 - N/C)
ATM	Low	81.8 (71.2 - N/C)	1.469 (.905 - 2.385)	0.119	1.273 (0.770 - 2.103)	0.346	N/C	2.129 (1.112 - 4.031)	0.02	1.713 (0.887 - 3.309)	0.109
	High	57.6 (44.6 - 72.4)					43.8 (31.4 - 73.7)
MSI/S	MSI	N/C	2.094 (1.379 - 3.180)	<0.01	1.570 (1.012 - 2.435)	0.044	N/C	2.105 (1.321 - 3.352)	<0.01	1.385 (0.851 - 2.252)	0.189
	MSS	48.7 (35.9 - 67.5)					42.5 (25.8 - 59.6)
HER2	Low	64.0 (48.5 – 77.5)	0.969 (0.579 - 1.640)	0.907	1.014 (0.578 – 1.777)	0.961	57.3 (39.4 - 79.8)	1.091 (0.620 – 1.921)	0.762	1.101 (0.597 – 2.029)	0.758
	High	51.8 (24.9 - N/C)					21.6 (11.6 - N/C)