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Regulation of myogenesis by MyoD1 activation of muscle genes. In myoblasts, MyoD1 associates with histone deacetylases (HDACs), leading to repression of muscle genes. During differentiation, MyoD1 interacts with histone acetyl transferases (HATs) to deposit acetylation (Ac) on histones of MyoD1 target genes. Acetylation of these muscle target genes promotes muscle fate determination.
