Table 2: Respiratory Parameters and Prescription Asthma Medication.
Mean (standard deviation) of cumulative inspired oxygen exposure (FiO2AUC), cumulative mean airway pressure (MAPAUC), intermittent hypoxemia events per day, and mean oxygen saturation (SpO2) at Days 1–3, 1–7, and 1–28 of postnatal age. Relative Risk (95% Confidence Intervals) and p-values reported for variable’s association with reported prescription asthma medication (Yes) or no respiratory medications (No) within the past 6 months of child’s two year follow-up visit by generalized estimating equations (GEE) for Poisson regression models with clustering of twins or triplets within one mother. Adjusted for gestational age (weeks completed) and sex. GEE iteration limit exceeded for adjusted RR of Day 1–28 cumulative oxygen exposure and asthma medication outcome.
| In Last 6 Months, Any Prescription Asthma Medication Used | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| mean(SD) | Day 1–3 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–7 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–28 | RR (95% CI) | p | Adjusted RR (95% CI) | p | |||
| Yes | No | Yes | No | Yes | No | |||||||||||||
| FiO2AUC (% × day) | 96.4 (31.1) | 87.7 (21.6) | 1.01 (1.001, 1.01) | .02 | 1.01 (1.0003, 1.01) | .04 | 202.5 (50.2) | 186.4 (33.9) | 1.004 (1.001, 1.01) | .009 | 1.004 (1.001,1.01) | .02 | 920.2 (271.6) | 865.2 (241.8) | 1.00 (1.00,1.00) | .10 | No estimates: Iteration limit exceeded | - |
| MAPAUC (cm H2O × day) | 19.7 (5.7) | 18.0 (4.1) | 1.03 (1.01, 1.06) | .02 | 1.03 (0.99, 1.06) | .052 | 42.9 (16.7) | 38.3 (12.9) | 1.01 (1.0004, 1.02) | .04 | 1.01 (0.99,1.02) | .09 | 169.0 (74.4) | 157.2 (72.2) | 1.00 (1.00, 1.00) | .28 | 1.00 (1.00,1.01) | .41 |
| Intermittent Hypoxemia (per day) | 33 (33) | 21 (17) | 1.01 (1.004,1.01) | .0002 | 1.01 (1.004, 1.01) | <.0001 | 31 (24) | 21 (15) | 1.01 (1.01,1.02) | <.0001 | 1.01 (1.01,1.02) | .0005 | 98 (58) | 83 (51) | 1.00 (1.00, 1.01) | .09 | 1.00 (1.00, 1.00) | .28 |
| Mean SpO2 (%) | 93.5 (2.5) | 94.5 (2.2) | 0.92 (0.87, 0.98) | .005 | 0.93 (0.88,0.98) | .005 | 93.7 (2.3) | 94.5 (1.9) | 0.91 (0.85,0.98) | .01 | 0.91 (0.86,0.99) | .02 | 92.7 (2.3) | 93.3 (2.4) | 0.94 (0.88,1.00) | .06 | 0.94 (0.88,1.01) | .09 |